The effect of moderete exercise on VEGF(Vascular Endothrlial Growth Factor) Expression during tooth socket wound healing after tooth extraction

• Main Authors: Anis Irmawati, Farris Zakki Giffari, Aqsa Sjuhada Oki
• Format: Article PeerReviewed
• Language: English; English; Indonesian; Indonesian
• Published: Journal Of Postgraduate Medical Institute 2018
• Subjects: R Medicine; RK Dentistry
• Online Access: http://repository.unair.ac.id/90134/1/2.%20TheEffectOfModerateExerciseOnVascularEndothelialGrowthFactorExpressionDuringToothSocketWoundHealingAfterToothExtraction-JMPI-Mar2018.pdf; http://repository.unair.ac.id/90134/3/2.%20turnitin-THE%20EFFECT%20OF%20MODERATE%20EXERCISE%20ON%20VASCULAR%20ENDOTHELIAL%20GROWTH%20FACTOR%20EXPRESSION%20DURING%20TOOTH%20SOCKET%20WOUND%20HEALING%20AFTER%20TOOTH%20EXTRACTION.pdf; http://repository.unair.ac.id/90134/6/pereview%202.pdf; http://repository.unair.ac.id/90134/7/The%20ffict%20of%20moderete%20exercise%20on%20Aqsa.pdf; http://repository.unair.ac.id/90134/; https://www.jpmi.org.pk/index.php/jpmi/article/view/2188/1954
• Institution: Universitas Airlangga

Objective: To determine vascular endothelial growth factor (VEGF) expression during the tooth socket wound healing process post-extraction after moderate exercise. Methodology: Wistar Rats (Rattus norvegicus) were divided into control group(group I) and treatment group (group II). The group II was given moderate exercise with 50% maximal work capacity of time, every day, for 2 weeks. The VEGF expression was observed in macrophages 3 days after tooth extraction and analyzed using immunohistochemistry. Statistical analysis was conducted using an independent t-test. Results: The treatment group had a higher expression of mean VEGF as compared to the control group (194.43 +17.213 vs. 131.29 +21.085, respectively). The difference in test results of VEGF expressions was significant, with a p value of =0.000. Conclusion: Moderate exercise increased the expression of VEGF during the tooth socket wound healing process after tooth extraction.