PENGARUH KOMBINASI POLIMER DALAM PATCH TIPE MATRIKS TERHADAP EFEKTIVITAS ANTIINFLAMASI MELOKSIKAM (Kombinasi Polimer : Natrium Alginat, Hidroksi Propil Metil Selulosa E15, Etil Selulosa N22)
Meloxicam is an NSAID drug that can cause gastric irritation in oral administration. Transdermal drug delivery system as matrix type-patch can avoid its side effect. This study aimed to determine the effect of hydrophilic and hydrophobic polymer combinations to anti-inflammatory effect of matrix...
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2019
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id-langga.905392019-11-07T04:18:40Z http://repository.unair.ac.id/90539/ PENGARUH KOMBINASI POLIMER DALAM PATCH TIPE MATRIKS TERHADAP EFEKTIVITAS ANTIINFLAMASI MELOKSIKAM (Kombinasi Polimer : Natrium Alginat, Hidroksi Propil Metil Selulosa E15, Etil Selulosa N22) ESTI ROSSA LARASATI, 051511133003 RS1-441 Pharmacy and materia medica Meloxicam is an NSAID drug that can cause gastric irritation in oral administration. Transdermal drug delivery system as matrix type-patch can avoid its side effect. This study aimed to determine the effect of hydrophilic and hydrophobic polymer combinations to anti-inflammatory effect of matrix type-meloxicam patch. Two formulations of meloxicam patches were composed of sodium alginate, hydroxyl propyl methyl cellulose E15 (HPMC E15) and ethyl cellulose N22 (EC N22) in ratios of 4.5: 5: 1.5 as a formula 1 and 5: 4.5: 1.5 as formula 2. The matrix type-transdermal patch of meloxicam was prepared by mixing all dispersion polymers matrix and meloxicam. The matrix type-transdermal patch was evaluated for organoleptic properties, weight variation, moisture content, flatness, the surface morphology of matrix type-transdermal patch, drug content and homogeneity. All independent variables had no significant effect on the dependent variables (p-values > 0.05) using independent Sample T-test except the moisture content. The rat paw edema test was performed to evaluate the anti-inflammatory effect of matrix type-transdermal meloxicam patch. Thus, formula 1 had provided more effective anti-inflammatory effect than formula 2. 2019 Thesis NonPeerReviewed text en http://repository.unair.ac.id/90539/1/FF.F.05-19%20Lar%20p%20abstrak.pdf text en http://repository.unair.ac.id/90539/2/FF.F.05-19%20Lar%20p%20daftar%20isi.pdf text en http://repository.unair.ac.id/90539/3/FF.F.05-19%20Lar%20p%20daftar%20pustaka.pdf text id http://repository.unair.ac.id/90539/4/FF.F.05-19%20Lar%20p.pdf ESTI ROSSA LARASATI, 051511133003 (2019) PENGARUH KOMBINASI POLIMER DALAM PATCH TIPE MATRIKS TERHADAP EFEKTIVITAS ANTIINFLAMASI MELOKSIKAM (Kombinasi Polimer : Natrium Alginat, Hidroksi Propil Metil Selulosa E15, Etil Selulosa N22). Skripsi thesis, UNIVERSITAS AIRLANGGA. http://lib.unair.ac.id |
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RS1-441 Pharmacy and materia medica ESTI ROSSA LARASATI, 051511133003 PENGARUH KOMBINASI POLIMER DALAM PATCH TIPE MATRIKS TERHADAP EFEKTIVITAS ANTIINFLAMASI MELOKSIKAM (Kombinasi Polimer : Natrium Alginat, Hidroksi Propil Metil Selulosa E15, Etil Selulosa N22) |
description |
Meloxicam is an NSAID drug that can cause gastric irritation in oral
administration. Transdermal drug delivery system as matrix type-patch can
avoid its side effect. This study aimed to determine the effect of hydrophilic
and hydrophobic polymer combinations to anti-inflammatory effect of matrix
type-meloxicam patch. Two formulations of meloxicam patches were
composed of sodium alginate, hydroxyl propyl methyl cellulose E15 (HPMC
E15) and ethyl cellulose N22 (EC N22) in ratios of 4.5: 5: 1.5 as a formula 1
and 5: 4.5: 1.5 as formula 2. The matrix type-transdermal patch of meloxicam
was prepared by mixing all dispersion polymers matrix and meloxicam.
The matrix type-transdermal patch was evaluated for organoleptic
properties, weight variation, moisture content, flatness, the surface
morphology of matrix type-transdermal patch, drug content and
homogeneity. All independent variables had no significant effect on the
dependent variables (p-values > 0.05) using independent Sample T-test
except the moisture content. The rat paw edema test was performed to
evaluate the anti-inflammatory effect of matrix type-transdermal meloxicam
patch. Thus, formula 1 had provided more effective anti-inflammatory effect
than formula 2. |
format |
Theses and Dissertations NonPeerReviewed |
author |
ESTI ROSSA LARASATI, 051511133003 |
author_facet |
ESTI ROSSA LARASATI, 051511133003 |
author_sort |
ESTI ROSSA LARASATI, 051511133003 |
title |
PENGARUH KOMBINASI POLIMER DALAM PATCH TIPE MATRIKS TERHADAP
EFEKTIVITAS ANTIINFLAMASI MELOKSIKAM
(Kombinasi Polimer : Natrium Alginat, Hidroksi Propil
Metil Selulosa E15, Etil Selulosa N22) |
title_short |
PENGARUH KOMBINASI POLIMER DALAM PATCH TIPE MATRIKS TERHADAP
EFEKTIVITAS ANTIINFLAMASI MELOKSIKAM
(Kombinasi Polimer : Natrium Alginat, Hidroksi Propil
Metil Selulosa E15, Etil Selulosa N22) |
title_full |
PENGARUH KOMBINASI POLIMER DALAM PATCH TIPE MATRIKS TERHADAP
EFEKTIVITAS ANTIINFLAMASI MELOKSIKAM
(Kombinasi Polimer : Natrium Alginat, Hidroksi Propil
Metil Selulosa E15, Etil Selulosa N22) |
title_fullStr |
PENGARUH KOMBINASI POLIMER DALAM PATCH TIPE MATRIKS TERHADAP
EFEKTIVITAS ANTIINFLAMASI MELOKSIKAM
(Kombinasi Polimer : Natrium Alginat, Hidroksi Propil
Metil Selulosa E15, Etil Selulosa N22) |
title_full_unstemmed |
PENGARUH KOMBINASI POLIMER DALAM PATCH TIPE MATRIKS TERHADAP
EFEKTIVITAS ANTIINFLAMASI MELOKSIKAM
(Kombinasi Polimer : Natrium Alginat, Hidroksi Propil
Metil Selulosa E15, Etil Selulosa N22) |
title_sort |
pengaruh kombinasi polimer dalam patch tipe matriks terhadap
efektivitas antiinflamasi meloksikam
(kombinasi polimer : natrium alginat, hidroksi propil
metil selulosa e15, etil selulosa n22) |
publishDate |
2019 |
url |
http://repository.unair.ac.id/90539/1/FF.F.05-19%20Lar%20p%20abstrak.pdf http://repository.unair.ac.id/90539/2/FF.F.05-19%20Lar%20p%20daftar%20isi.pdf http://repository.unair.ac.id/90539/3/FF.F.05-19%20Lar%20p%20daftar%20pustaka.pdf http://repository.unair.ac.id/90539/4/FF.F.05-19%20Lar%20p.pdf http://repository.unair.ac.id/90539/ http://lib.unair.ac.id |
_version_ |
1681152849055055872 |