PENGARUH SISTEM DISPERSI PADATANDROGRAFOLIDA-KITOSAN TERHADAP AKTIVITAS ANTI MALARIA SECARA IN VIVO PADA MENCIT TERINFEKSI Plasmodium berghei
Andrographolide (ADG) is a diterpene lactone derived from the herb Sambiloto (Andrographis paniculate) which have some of pharmacological effects. Its poorly soluble in water causes limited absorption and bioavailability. Solid dispersion systems can be used to increase the solubility and dissol...
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| Main Author: | |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | English English English Indonesian |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/90559/1/FF.F.07-19%20Ang%20p%20abstrak.pdf http://repository.unair.ac.id/90559/2/FF.F.07-19%20Ang%20p%20daftar%20isi.pdf http://repository.unair.ac.id/90559/3/FF.F.07-19%20Ang%20p%20daftar%20pustaka.pdf http://repository.unair.ac.id/90559/4/FF.F.07-19%20Ang%20p.pdf http://repository.unair.ac.id/90559/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | English English English Indonesian |
| Summary: | Andrographolide (ADG) is a diterpene lactone derived from the
herb Sambiloto (Andrographis paniculate) which have some of
pharmacological effects. Its poorly soluble in water causes limited absorption
and bioavailability. Solid dispersion systems can be used to increase the
solubility and dissolution rate of medical substances with low water
solubility. Solid dispersion systems of andrographolide-chitosan (SDS ADGCTS)
is prepared by the solubilization-spray drying method. The purpose of
this study was to determine the effect of andrographolide-chitosan solid
dispersion system on the antimalarial activity in Plasmodium berghei
infected mice. Characterization of andrographolide-chitosan solid dispersion
system using SEM showed the shape of spherical, DTA showed decrease
endothermic peak and a lower melting point in the solid dispersion system,
and X-ray difactogram showed a decrease in the intensity of the diffraction
showing the crystallinity of andrographolide. In vivo antimalarial test was
done using Peter’s 4 days suppressive test. The result showed the in vivo
antimalarial activity of andrographolide-chitosan solid dispersion systems
increase inhibition of andrographolide against Plasmodium berghei mice
infected. Its average percentage inhibition at fifth day is 54,71± 2,14% and
increased by 1,56 times if compared with andrographolide. |
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