PENGARUH KONSENTRASI METILSELULOSA 4 mPa.s TERHADAP KARAKTERISTIK FISIK DAN LAJU DISOLUSI BEADS TERSALUT NANOSUSPENSI KERING HESPERETIN-POLOKSAMER 188
The aim of this study was to determine the effect of methylcellulose 4 mPa.s concentrations as coating polymer on dissolution rate and physical characteristics of beads coated dried hesperetin-poloxamer 188. The initial hesperetin (HPT) nanosuspension was formed using poloxamer 188 (P188) 29% (w...
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Format: | Theses and Dissertations NonPeerReviewed |
Language: | English English English Indonesian |
Published: |
2019
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Subjects: | |
Online Access: | http://repository.unair.ac.id/90640/1/FF.F.11-19%20Pri%20p%20abstrak.pdf http://repository.unair.ac.id/90640/2/FF.F.11-19%20Pri%20p%20daftar%20isi.pdf http://repository.unair.ac.id/90640/3/FF.F.11-19%20Pri%20p%20daftar%20pustaka.pdf http://repository.unair.ac.id/90640/4/FF.F.11-19%20Pri%20p.pdf http://repository.unair.ac.id/90640/ http://lib.unair.ac.id |
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Institution: | Universitas Airlangga |
Language: | English English English Indonesian |
Summary: | The aim of this study was to determine the effect of methylcellulose 4
mPa.s concentrations as coating polymer on dissolution rate and physical
characteristics of beads coated dried hesperetin-poloxamer 188. The initial
hesperetin (HPT) nanosuspension was formed using poloxamer 188 (P188)
29% (w/w) processed with top down wet ball milling (target size of <200
nm). The HPT-P188 nanosuspension was then added with two different
concentrations of methylcellulose 25% (F1) and 50% (F2) (w/w), PEG 6000
and tartrazine. Those nanosuspensions were then evaluated for its particle
size, content and dissolution. Furthermore, those nanosuspensions were then
conventionally dried in an oven at 50C. Separately, nanosuspensions of
HPT-P188-methylcelluose were then used to coat beads sized 710-850 μm.
The beads layered with the dried nanosuspensions were also evaluated for
their morphology and release of hesperetin. The results showed that
nanosuspensions, with or without the methylcellulose, released hesperetin
within <30 minutes and instantly reached 100%. The percentage of dissolved
nanosuspension dried with oven and coated beads HPT-P188 conventionally
dried nanosuspensions decreased and not identical with their
nanosuspensions. Morphology of the dried nanosuspension and coated beads
was observed using SEM. The diffractogram showed that during the milling
and drying at 50℃, hesperetin was still in its crystalline form and with the
addition of MC, the diffraction peak decreased. However, in coated beads the
diffraction peak were only dominated by the core beads, because of the
coating thickness. Methylcellulose in both F1 and F2 were not able to prevent
nanocrystal agglomeration hence altered the release of hesperetin. |
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