PENGARUH PENAMBAHAN PVP K30 TERHADAP KO-PROSES KOMBINASI MIKROKRISTALIN SELULOSA PH101 DAN MALTITOL SEBAGAI CUSHIONING AGENT PADA TABLET MULTIPLE UNIT PELLET SYSTEM (MUPS) METFORMIN HCl
The aim of this research was to investigate the effect of PVP K30 addition on the co-processed combination of microcrystalline cellulose (MCC) PH101 and maltitol combination co-processed as cushioning agent and discover optimum ratio of MCC PH101:maltitol:PVP K30 that could protect pellets. Thus...
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Format: | Theses and Dissertations NonPeerReviewed |
Language: | English English English Indonesian |
Published: |
2019
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Subjects: | |
Online Access: | http://repository.unair.ac.id/90648/1/FF.F.17-19%20Aug%20p%20abstrak.pdf http://repository.unair.ac.id/90648/2/FF.F.17-19%20Aug%20p%20daftar%20isi.pdf http://repository.unair.ac.id/90648/3/FF.F.17-19%20Aug%20p%20daftar%20pustaka.pdf http://repository.unair.ac.id/90648/4/FF.F.17-19%20Aug%20p.pdf http://repository.unair.ac.id/90648/ http://lib.unair.ac.id |
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Institution: | Universitas Airlangga |
Language: | English English English Indonesian |
Summary: | The aim of this research was to investigate the effect of PVP K30
addition on the co-processed combination of microcrystalline cellulose
(MCC) PH101 and maltitol combination co-processed as cushioning agent
and discover optimum ratio of MCC PH101:maltitol:PVP K30 that could
protect pellets. Thus, good physical characteristics of tablet MUPS was
produced. Hydrophilic polymer PVP K30 was plastic material that could
used as binder. Two different formulas ratios of MCC PH101:maltitol:PVP
K30 (5:1:0.3 and 5:1:0.7 w/w) were optimized. These cushioning agents
were made by co-process which include wet ball milling and spray drying.
Cushioning agents were evaluated for their physicochemical and
mechanical characteristics. Mechanical characteristics was analyzed using
Heckel-plot to obtained py value. Result showed that addition of PVP K30
couldn’t increase its plasticity of the co-process obtained. MUPS tablets
were evaluated to determine its physical properties of tablet. Moreover,
dissolution studies was used to determine the optimum cushioning agent
that could protect pellets from damaged caused by compaction. Differential
factor (f1) and similarity factor (f2) were applied to evaluate dissolution
profiles of MUPS tablets. The f1 dan f2 values of MUPS tablet with MCC
PH101:maltitol:PVP K30 5:1:0.3 combination were 12.25 and 56.84. It
showed that dissolution studies of those combination had the most similar
value with dissolution profile of uncompacted pellets as control. However,
dissolution profile MUPS tablet compacted with MCC PH101:maltitol:PVP
K30 5:1:0.7 showed difference compared to the dissoultion profile of
uncompacted pellets as control. In conclusion, increasing level of PVP K30
did not affect plasticity hence failed to protect pellets from damaged. |
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