PENGARUH JUMLAH KOPOLIMER EUDRAGIT L100 TERHADAP KARAKTERISTIK FISIK MIKROPARTIKEL RUTIN
Routine is a flavonoid compound that has pharmacology effect as antihipertension and antioxidant but it was known that routine was hydrolized by acid environment and low solubility in water. Microparticle system was known to be used to protect drug compound that unstable to acid and increase dru...
Saved in:
| Main Author: | |
|---|---|
| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | English English English Indonesian |
| Published: |
2019
|
| Subjects: | |
| Online Access: | http://repository.unair.ac.id/90661/1/FF.F.31-19%20Per%20p%20abstrak.pdf http://repository.unair.ac.id/90661/2/FF.F.31-19%20Per%20p%20daftar%20isi.pdf http://repository.unair.ac.id/90661/3/FF.F.31-19%20Per%20p%20daftar%20pustaka.pdf http://repository.unair.ac.id/90661/4/FF.F.31-19%20Per%20p.pdf http://repository.unair.ac.id/90661/ http://lib.unair.ac.id |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universitas Airlangga |
| Language: | English English English Indonesian |
| Summary: | Routine is a flavonoid compound that has pharmacology effect as
antihipertension and antioxidant but it was known that routine was hydrolized
by acid environment and low solubility in water. Microparticle system was
known to be used to protect drug compound that unstable to acid and increase
drug solubility. As a acidic protector, microparticle was made from polymer
that undissolved in acid and can be dissolved in base. Eudragit L100 was
known as a polymer that have pH based solubility, it was dissolved at pH 6
and higher. Using eudragit L100, microparticle can providing acid protection
ability to routine with swelling mechanism. This study aimed to investigate
the effect of eudragit L100 copolymer amount on routine microparticle
thermal properties, entrapment efficiency, and swelling index of
microparticle. This research was using three formulas that have three
different ratio on routine - eudragit L100. Rutin – eudragit L100 microparticle
was prepared by dissolve the rutin and eudragit L100 and then, the solution
was dried by spray drying. The microparticle was evaluated to determine
thermal properties, entrapment efficiency, and swelling index. The physical
characteristic was analyzed using DTA for thermal analysis, showed that all
ratio of routine – eudragit L100 microparticle has amorphous form by single
endothermal peak, the data was supported by X-ray diffractogram showed
that there is no high intensity peak; the entrapment efficiency of routine was
evaluated using UV-Vis spectrophotometry showed that the efficiency was
increase as the increase of eudragit L100 used on formula; the swelling index
of microparticle evaluated in pH 1.2 acidic solution, it was showed the
swelling value was increased as the increase of eudragit L100 used on
formula. |
|---|