KADAR PRIMAKUIN DAN KLOROKUIN DALAM DARAH SEBAGAI SEDIAAN LIPOSOM DENGAN RUTE PEMBERIAN INTRAVENA
Malaria is divided into two types, namely erythrocytic and hepatic malaria. Primaquine (PQ), which belongs to the 8-aminoquinoline group, is the only effective antimalarial drug in the hepatic phase, but this drug has the effect of hemolytic anemia in patients with glucose-6-Phosphate dehydrogen...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | English English English Indonesian |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/90667/1/FF.F.36-19%20Neh%20k%20abstrak.pdf http://repository.unair.ac.id/90667/2/FF.F.36-19%20Neh%20k%20daftar%20isi.pdf http://repository.unair.ac.id/90667/3/FF.F.36-19%20Neh%20k%20daftar%20pustaka.pdf http://repository.unair.ac.id/90667/4/FF.F.36-19%20Neh%20k.pdf http://repository.unair.ac.id/90667/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | English English English Indonesian |
| Summary: | Malaria is divided into two types, namely erythrocytic and hepatic
malaria. Primaquine (PQ), which belongs to the 8-aminoquinoline group,
is the only effective antimalarial drug in the hepatic phase, but this drug
has the effect of hemolytic anemia in patients with glucose-6-Phosphate
dehydrogenase (G6PDase) deficiency. Chloroquine also has potent
activity against the asexual stage (erythrocytic stage), but has no activity
against hypnozoites. The use of primaquine with chloroquine in therapy
has been reported to increase the effectiveness of primaquine and can
reduce the toxicity of primaquine. In this research, biodistribution tests
were carried out in vivo on liposome primaquine and chloroquine
liposome mice and combinations compared chloroquine. Liposomes and
free drugs injected equivalent to doses of primaquine and chloroquine,
which are 3.5 mg and 1.8 mg / kg BB mice. After 24 hours of drugs
administration, the blood level of primaquine and chloroquine wiil be
determination using HPLC. The result shored about 86,21% anf 72,92%
injected dose of chloroquine were observe for liposome chloroquine and
liposome combination of chloroquine and primaquine, while it is only
14,62% detected after free drugs administration. An the other hand ,
primaquine not be quantified because no specific read well before during
the analysis. It can be that the chloroquine drug in the preparation of
liposomes has proven effective compared to free drug, as evidence condition liposome could improve systemic blood syrculation of
chloroquine. |
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