PENGARUH PERBANDINGAN D-α- TOCOPHERYL POLYETHYLENE GLYCOL 1000 SUCCINATE (TPGS) DAN POLOKSAMER 188 TERHADAP KARAKTERISTIK FISIK DAN STABILITAS MISEL KOMBINASI (MIXED MICELLES) (Untuk Pengembangan Sistem Penghantaran Hesperetin)
Hesperetin a flavonoid compound of citrus fruit has a many pharmacological effects. Hesperetin has a poor solubility in water and fast elimination from the body causes low bioavailability of this compound when given orally. Formulating hesperetin as micelles sistem could overcome these problems....
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian English English English |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/90704/1/FF.F.44-19%20Sof%20p.pdf http://repository.unair.ac.id/90704/2/FF.F.44-19%20Sof%20p%20daftar%20pustaka.pdf http://repository.unair.ac.id/90704/3/FF.F.44-19%20Sof%20p%20daftar%20isi.pdf http://repository.unair.ac.id/90704/4/FF.F.44-19%20Sof%20p%20abstrak.pdf http://repository.unair.ac.id/90704/ |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian English English English |
| Summary: | Hesperetin a flavonoid compound of citrus fruit has a many
pharmacological effects. Hesperetin has a poor solubility in water and fast
elimination from the body causes low bioavailability of this compound
when given orally. Formulating hesperetin as micelles sistem could
overcome these problems. Additionally, the use of micelles compound such
as TPGS and poloxamer 188 as mixed micelles were known had synergism
effect to improve their each lacks. The aim of the study is to investigate the
effect of different ratio TPGS:poloxamer 188 on physical characteristic and
stability of mixed micelles. The mixed micelles were prepared by thin film
hydration method. Particle size of all mixed micelles analyzed using
dynamic light scattering sizer, it was shown mixed micelles
TPGS:poloxamer 188 with ratio 1:4 resulted bigger particle size than ratio
1:1 and 1:2. CMC of mixed micelles TPGS:poloxamer 188 is lower than
CMC of single TPGS micelles. The encapsulation efficiency of mixed
micelles TPGS:poloxamer 188 also greater than single TPGS micelles. The
lowest CMC and greatest encapsulation efficiency was obtained in mixed
micelles TPGS:poloxamer 188 with ratio 1:4. Dilution stability test was
observed visually and mixed micelles showed no precipitation in ratio 1:2
and 1:4. The conclusion, increasing amount of poloxamer 188 in mixed
micelles could form bigger particle size, lower CMC, greater encapsulation
efficiency. |
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