STUDI PERBANDINGAN PELEPASAN DAN STABILITAS FISIK APMS DALAM SISTEM NANOSTRUCTURED LIPID CARRIERS (NLC), SOLID LIPID NANOPARTICLES (SLN), DAN NANOEMULSI (NE) (Lipid Padat Kombinasi Oleum Cacao-Beeswax dan Lipid Cair Minyak Zaitun)
PMCA is an anti-inflammatory which has low solubility in water so it can affect the drug release rate, the rate of penetration, and its effectiveness. To overcome this problem, there are some drug carrier systems that can be used, namely NLC, SLN, and NE. The difference among these three systems...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | English English English Indonesian |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/90705/1/FF.F.45-19%20Rac%20s%20abstrak.pdf http://repository.unair.ac.id/90705/2/FF.F.45-19%20Rac%20s%20daftar%20isi.pdf http://repository.unair.ac.id/90705/3/FF.F.45-19%20Rac%20s%20daftar%20pustaka.pdf http://repository.unair.ac.id/90705/4/FF.F.45-19%20Rac%20s.pdf http://repository.unair.ac.id/90705/ |
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| Institution: | Universitas Airlangga |
| Language: | English English English Indonesian |
| Summary: | PMCA is an anti-inflammatory which has low solubility in water so
it can affect the drug release rate, the rate of penetration, and its
effectiveness. To overcome this problem, there are some drug carrier
systems that can be used, namely NLC, SLN, and NE. The difference
among these three systems is the composition of the lipid phase. The lipid
phase of NE is only consist of liquid lipids, whereas SLN is only consist of
solid lipids, and the lipid phase of NLC is a combination of liquid solid
lipid. The composition of solid and liquid lipids can affect the
characteristics and the drug release rate of the system. The purpose of this
study is to compare the drug release rate of APMS from the NLC, SLN, and
NE systems and the physical stability of the system with the real time
method. Evaluation characteristics include organoleptic, pH, particle size
and PI, viscosity, melting point and crystallization index, and entrapment
efficiency. The results obtained NE-APMS has the largest drug release rate
(0.4690 μg/cm2.minute) which can be influenced by the characteristics of
NE-APMS which has a low viscosity and small particle size. The results of
the physical stability test (color, odor, and consistency) of the system with
real time methods show that NLC-APMS is the most stable system. |
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