Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence
The association between gastroesophageal reflux disease (GERD) prevalence and its risk factors in an area with low Helicobacter pylori prevalence is important to clarify. We analyzed the prevalence of GERD and risk factors in an area of Indonesia with low prevalence of H. pylori infection. We recrui...
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2018
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id-langga.908852021-02-26T03:53:11Z http://repository.unair.ac.id/90885/ Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence Muhammad Miftahussurur Dalla Doohan Iswan Abbas Nusi Pangestu Adi Yudith Annisa Ayu Rezkitha Langgeng Agung Waskito Kartika Afrida Fauzia Taufan Bramantoro Ummi Maimunah Husin Thamrin Safitri Indah Masithah Sukadiono Tomohisa Uchida Maria Inge Lusida Yoshio Yamaoka R Medicine (General) RC Internal medicine The association between gastroesophageal reflux disease (GERD) prevalence and its risk factors in an area with low Helicobacter pylori prevalence is important to clarify. We analyzed the prevalence of GERD and risk factors in an area of Indonesia with low prevalence of H. pylori infection. We recruited 104 dyspeptic patients who underwent endoscopy in Surabaya. Patients were diagnosed with GERD based on the Los Angeles classification. We evaluated gastric biopsy specimens and measured serum pepsinogen levels. Interleukin polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism. Of 104 patients, 56 (53.8%) were endoscopically found to have GERD, with most categorized as grade A; 48 (46.2%) were classified as non-GERD. Higher economic status, smoking, and a history of proton-pump inhibitor use significantly increased the risk of GERD. GERD Questionnaire scores showed a positive correlation with GERD (P < 0.001). An association was found between antral atrophic gastritis and GERD (P = 0.030), and patients with GERD more frequently had severe antral atrophy than nonerosive reflux disease (P = 0.018). We found an association between pepsinogen I/II levels and GERD (P = 0.047), but with low accuracy. IL-1β -511 TT and CT were predominant among the IL-1β -511 genotypes, and IL-8–251 AT and TT were predominant among the IL-8–251 genotypes. In conclusion, we found a high prevalence of GERD in an area with low prevalence of H. pylori infection, which could be associated with acid reflux. Smoking, history of proton-pump inhibitor use, and higher economic group significantly increased the risk of GERD. Public Library of Science 2018-11 Article PeerReviewed text en http://repository.unair.ac.id/90885/1/9.%20Gastroesophageal%20reflux%20disease%20in%20an%20area%20with%20low%20Helicobacter%20pylori%20infection%20prevalence_compressed.pdf text en cc_by_4 http://repository.unair.ac.id/90885/2/Gastroesofageal%20Reflux%20Disease%20in%20an%20Area%20with%20Helicobacter%20pylori%20Infection%20Prevalence.pdf text en http://repository.unair.ac.id/90885/6/gastroesophageal.pdf text en http://repository.unair.ac.id/90885/8/Gastroesophageal%20reflux.pdf Muhammad Miftahussurur and Dalla Doohan and Iswan Abbas Nusi and Pangestu Adi and Yudith Annisa Ayu Rezkitha and Langgeng Agung Waskito and Kartika Afrida Fauzia and Taufan Bramantoro and Ummi Maimunah and Husin Thamrin and Safitri Indah Masithah and Sukadiono and Tomohisa Uchida and Maria Inge Lusida and Yoshio Yamaoka (2018) Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence. Plos One, 13 (11). pp. 1-15. ISSN 1549-1676 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205644 https://doi.org/10.1371/journal.pone.0205644 |
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R Medicine (General) RC Internal medicine Muhammad Miftahussurur Dalla Doohan Iswan Abbas Nusi Pangestu Adi Yudith Annisa Ayu Rezkitha Langgeng Agung Waskito Kartika Afrida Fauzia Taufan Bramantoro Ummi Maimunah Husin Thamrin Safitri Indah Masithah Sukadiono Tomohisa Uchida Maria Inge Lusida Yoshio Yamaoka Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence |
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The association between gastroesophageal reflux disease (GERD) prevalence and its risk factors in an area with low Helicobacter pylori prevalence is important to clarify. We analyzed the prevalence of GERD and risk factors in an area of Indonesia with low prevalence of H. pylori infection. We recruited 104 dyspeptic patients who underwent endoscopy in Surabaya. Patients were diagnosed with GERD based on the Los Angeles classification. We evaluated gastric biopsy specimens and measured serum pepsinogen levels. Interleukin polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism. Of 104 patients, 56 (53.8%) were endoscopically found to have GERD, with most categorized as grade A; 48 (46.2%) were classified as non-GERD. Higher economic status, smoking, and a history of proton-pump inhibitor use significantly increased the risk of GERD. GERD Questionnaire scores showed a positive correlation with GERD (P < 0.001). An association was found between antral atrophic gastritis and GERD (P = 0.030), and patients with GERD more frequently had severe antral atrophy than nonerosive reflux disease (P = 0.018). We found an association between pepsinogen I/II levels and GERD (P = 0.047), but with low accuracy. IL-1β -511 TT and CT were predominant among the IL-1β -511 genotypes, and IL-8–251 AT and TT were predominant among the IL-8–251 genotypes. In conclusion, we found a high prevalence of GERD in an area with low prevalence of H. pylori infection, which could be associated with acid reflux. Smoking, history of proton-pump inhibitor use, and higher economic group significantly increased the risk of GERD. |
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Article PeerReviewed |
author |
Muhammad Miftahussurur Dalla Doohan Iswan Abbas Nusi Pangestu Adi Yudith Annisa Ayu Rezkitha Langgeng Agung Waskito Kartika Afrida Fauzia Taufan Bramantoro Ummi Maimunah Husin Thamrin Safitri Indah Masithah Sukadiono Tomohisa Uchida Maria Inge Lusida Yoshio Yamaoka |
author_facet |
Muhammad Miftahussurur Dalla Doohan Iswan Abbas Nusi Pangestu Adi Yudith Annisa Ayu Rezkitha Langgeng Agung Waskito Kartika Afrida Fauzia Taufan Bramantoro Ummi Maimunah Husin Thamrin Safitri Indah Masithah Sukadiono Tomohisa Uchida Maria Inge Lusida Yoshio Yamaoka |
author_sort |
Muhammad Miftahussurur |
title |
Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence |
title_short |
Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence |
title_full |
Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence |
title_fullStr |
Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence |
title_full_unstemmed |
Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence |
title_sort |
gastroesophageal reflux disease in an area with low helicobacter pylori infection prevalence |
publisher |
Public Library of Science |
publishDate |
2018 |
url |
http://repository.unair.ac.id/90885/1/9.%20Gastroesophageal%20reflux%20disease%20in%20an%20area%20with%20low%20Helicobacter%20pylori%20infection%20prevalence_compressed.pdf http://repository.unair.ac.id/90885/2/Gastroesofageal%20Reflux%20Disease%20in%20an%20Area%20with%20Helicobacter%20pylori%20Infection%20Prevalence.pdf http://repository.unair.ac.id/90885/6/gastroesophageal.pdf http://repository.unair.ac.id/90885/8/Gastroesophageal%20reflux.pdf http://repository.unair.ac.id/90885/ https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205644 https://doi.org/10.1371/journal.pone.0205644 |
_version_ |
1693176945584373760 |