Macagigantin, a farnesylated flavonol from Macaranga gigantea

Macagigantin, a farnesylated flavonol from Macaranga gigantea

A new farnesylated flavonol derivative, macagigantin (1), together with two known flavonoids, glyasperin A (2) and apigenin (3), had been isolated from the acetone extract of the leaves of Macaranga gigantea. The structure of the new compound was elucidated as 6-farnesylkaempferol based on its spectro...

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Bibliographic Details
Main Authors: Mulyadi Tanjung, Euis H. Hakim, Didin Mujahidin, Muhammad Hanafi, Yana M. Syah
Format: Article PeerReviewed
Language:English
English
English
English
Published: Taylor & Francis 2009
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://repository.unair.ac.id/90941/1/C.01.%20Abstract.pdf
http://repository.unair.ac.id/90941/2/C.01.%20Fulltext%20%28Karya%20Ilmiah%29.pdf
http://repository.unair.ac.id/90941/8/C01_Validasi_Macagigantin%2C%20a%20farnesylated.pdf
http://repository.unair.ac.id/90941/4/C01_Similarity.pdf
http://repository.unair.ac.id/90941/
https://www.tandfonline.com/doi/abs/10.1080/10286020903302315
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Institution: Universitas Airlangga
Language: English
English
English
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Summary:A new farnesylated flavonol derivative, macagigantin (1), together with two known flavonoids, glyasperin A (2) and apigenin (3), had been isolated from the acetone extract of the leaves of Macaranga gigantea. The structure of the new compound was elucidated as 6-farnesylkaempferol based on its spectroscopic data, including UV, IR, 1D and 2D NMR, and HR-EI-MS spectra. Compounds 1–3 were evaluated for their cytotoxic properties against P-388 cells, their IC values being 11.3, 6.0, and 5.1 mM, respectively.

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