Antimalarial and Antioxidant Activities of Isoprenylated Coumarins from the Stem Bark of Mesua borneensis L.

• Main Authors: Mulyadi Tanjung, Ratih Dewi Saputri, Faiz Fakhriah Fitriati, Tjitjik Srie Tjahjandarie
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Taylor & Francis Online 2016
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://repository.unair.ac.id/90946/1/C.10.%20Abstract.pdf; http://repository.unair.ac.id/90946/2/C.10.%20Fulltext%20%28Karya%20Ilmiah%29.pdf; http://repository.unair.ac.id/90946/3/C10_Validasi__Antimalarial%20and%20Antioxidant%20Activities.pdf; http://repository.unair.ac.id/90946/4/C10_Similarity.pdf; http://repository.unair.ac.id/90946/; https://www.tandfonline.com/doi/abs/10.1080/22311866.2016.1188726; http://dx.doi.org/10.1080/22311866.2016.1188726
• Institution: Universitas Airlangga

The aim of this study was to assess the antimalarial and antioxidant effects of the n-hexane and ethyl acetate extracts together with three isolated isoprenylated coumarins, mammea A/BA(1),mammea A/ AA cyclo D (2) and mesuol (3) from the stem bark of M. borneensis L. The n-hexane and ethyl acetate extracts, as well as compounds 1-3 were evaluated for their antimalarial activity against Plasmodium falciparum strain 3D7 (chloroquine-sensitive) and their antioxidant activity against DPPH radical scavenging. Compound 2 exhibited slightly more active than chloroquine. Compounds 1 and 3 showed very high activity against DPPH radical.