Phenolic Compounds from The Stem Bark Erythrina Orientalis and Detection of Antimalaria Activity by ELISA

• Main Authors: Tjitjik Srie Tjahjandarie, Ratih Dewi Saputri, Mulyadi Tanjung
• Format: Book Section PeerReviewed
• Language: English; English; English; English
• Published: AIP Publishing 2016
• Subjects: Q Science; Q Science (General); QD Chemistry
• Online Access: http://repository.unair.ac.id/90972/2/C.20.%20Abstract.pdf; http://repository.unair.ac.id/90972/9/C.20.%20Fulltext%20%28Karya%20Ilmiah%29.pdf; http://repository.unair.ac.id/90972/8/C20_Validasi_Phenolic%20Compounds%20from%20.pdf; http://repository.unair.ac.id/90972/4/C20_Similarity.pdf; http://repository.unair.ac.id/90972/; https://aip.scitation.org/doi/10.1063/1.4943329; https://doi.org/10.1063/1.4943329
• Institution: Universitas Airlangga

Abstract. Erythrina orientalis has local name “Dadap”. This plant has known producing alkaloids, flavonoids, pterocarpans, stilbenes, and arylbenzofurans which are active compounds.Three prenylated flavonoids, 8prenyl-daidzein (1), alpinumisoflavone (2) and 4’-O-methyl licoflavanone (3) had been isolated from the stem bark of Erythrina Orientalis. The structures were elucidated on the basis of spectroscopic data,which ar IR, UV, MS, and NMR 1D ( 1 H-NMR and 13 C-NMR) and 2D (COSY, HMQC, and HMBC). Compounds 1-3 were evaluated for their antimalaria with ELISA methods, which showed percentage inhibitionvalues of74.46%, 62.06%, and 0% respectively. Based on the inhibition value showed 4’-O-methyl licoflavanone (1) exhibit very high antimalaria activity compared to compounds (2) and (3).