BMP-2 Expression of Post Tooth Extraction that Catfish Oil Application

• Main Authors: Theresia Indah Budhy S., Bambang Sumaryono, Ketut Suardita, Amelia Putri Rizkita
• Format: Article PeerReviewed
• Language: English; English; Indonesian
• Published: KnE Life Sciences 2017
• Subjects: R Medicine; RK Dentistry
• Online Access: http://repository.unair.ac.id/91650/1/6.pdf; http://repository.unair.ac.id/91650/3/BMP-2%20Expression%20of%20Post%20Tooth%20Extraction%20that%20Cat%EF%AC%81sh%20Oil%20Application.pdf; http://repository.unair.ac.id/91650/6/Validasi%20dan%20kelaikan%20Etik%20%28BMP%29.pdf; http://repository.unair.ac.id/91650/
• Institution: Universitas Airlangga

Background: Catfish (Clarias batrachus) oil contain the highest amount of omega- 3-PUFA among other freshwater fish. The omega-3-PUFA in fish oil produced eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). It is known that EPA and DHA in essentials fatty acid (EFA) could improve BMP-2 expression. Bone morphogenetic protein-2 (BMP-2) is bone stimulator which capable of inducing differentiation of mesenchymal cells into osteoblast, stimulating bone formation in wound healing process of dental extraction. Purpose: To prove the increasing expression of BMP-2 after catfish (Clarias batrachus) oil application. Methods: We have used the post test only design in this research. There have been 21 Rattus novergicus as research samples, and those were divided into 3 groups, group KK as control, group KP1 was given catfish (Clarias batrachus) oil in 5% concentration, and group KP2 was given catfish (Clarias batrachus) oil in 10% concentration. Catfish(Clarias batrachus) oil were applied into the socket of dental extraction. Rat was decapulated 7 days after fish oil application and the jaw in the treated regions and control group were cut for immunohistochemistry examination to observe BMP-2 expression. Data was analyzed using one-way ANOVA test. Result: There is significant difference increased of BMP-2 expression between control and treatment group. In samples given with 10% concentration of catfish oil had the most significant increase of BMP-2 expression. Conclusion: Catfish (Clarias batrachus) oil in 10% concentrationcould increase the expression of BMP-2 post dental extraction.