Pengaruh Infusa Mengkudu (Morinda Citrifolia) Terhadap Histopatologi Ginjal Mencit (Mus Muscullus) setelah Pemberian Pakan Tinggi Lemak

• Main Author: Eka Pramyrtha Hestianah
• Format: Article PeerReviewed
• Language: Indonesian; Indonesian
• Published: Bagian Anatomi-Histologi Fakultas Kedokteran Universitas Airlangga 2006
• Subjects: SF405.5-407 Laboratory animals; SF811-909 Veterinary medicine of special organs, regions, and systems
• Online Access: http://repository.unair.ac.id/92388/2/Bukti%2008.%20Pengaruh%20Infusa%20Mengkudu%20.....pdf; http://repository.unair.ac.id/92388/1/Peer%20Review%20Bukti%20C08_compressed.pdf; http://repository.unair.ac.id/92388/
• Institution: Universitas Airlangga

The purpose of the research is find out the effect of administration of Morindacitrifolia infusion to histological changes of mices kidney after the high fat intake. Twenty five male mices with average weight 30 gram devided into five groups. Group I is negative controle (PO-), got the standard feeding + 1ml aguadest. Group II is positive control (PO+ ), got the high fat intake + 1 ml aguadest. The others are treatment groups including : P1, P2, P3 got high fat intake and 20%, 40%, 60% Morindacitrifolia infusion. After 30 days of the treatment mices were sacrificed and made the H. E staining histological preparation of the mices kidney. Data analyses followed by H test and Wilcoxon's Rank Sum Test. The result followed : PO+, P1 showed the most severe cloudy swelling and glomerular enlargement, P2, P3 showed the severest medullary interstitial renal bleeding, PO-, P3 showed the mildest cortex interstitial renal bleeding Keywords :Morindracitrifolia infusion, histopathology of mices kidney