Lactic acid’s role in sodium hypertonic lactic solution as a neuroprotector measured from the level of ATP, MCT-1 and necrosis area in intracerebral hematoma rats model

• Main Authors: Hamzah, Nancy Margarita Rehatta, Tatang Bisri, Siti Chasnak Saleh, Arie Utariani
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Critical Care and Shock 2019
• Subjects: R Medicine (General); RZ Other systems of medicine
• Online Access: http://repository.unair.ac.id/92456/7/Lactic%20Acids%20role%20in.pdf; http://repository.unair.ac.id/92456/8/Lactic%20acids%20role%20in%20hypertonic.pdf; http://repository.unair.ac.id/92456/9/Lactic%20acidss%20role%20in%20sodium%20hypertonic%20lactic%20solution%20as%20a%20neuroprotector%20measured%20from%20the%20level%20of%20ATP%2C%20MCT-1%20and%20necrosis%20area%20in%20intracerebral%20hematoma%20rats%20model.pdf; http://repository.unair.ac.id/92456/; http://criticalcareshock.org/2019/04/lactic-acids-role-in-sodium-hypertonic-lactic-solution-as-a-neuroprotector-measured-from-the-level-of-atp-mct-1-and-necrosis-area-in-intracerebral-hematoma-rats-model/
• Institution: Universitas Airlangga

Objective: To discover the role of hypertonic sodium lactate (HSL) as the energy source, which in turn will act as a neuroprotector, by measuring adenosine triphosphate (ATP) level, monocarboxylate transporter 1 (MCT-1) and the extent of the necrotic areas. Design: This was an experimental study that used randomized post-test only control group design. Setting: Experimental Animal Care Unit Universitas Gadjah Mada. Patient and participant: 32 white mice of Rattus norvegicus. Intervention: After the protocol of this study was approved by the research ethic committee, 32 rats were randomly divided into two groups: HSL group (n=16) and NaCl 3% group (n=16) as the control group. Both groups were anesthetized using conversion-dose pentothal. Results: ATP level in HSL group was higher compared to the control group (p=0.031). MCT-1 in HSL group was also higher than the control group (p=0.010). Necrotic areas were less extensive in the HSL group than the control group (p=0.000). Lactate levels at minute 30 (T30) and minute 360 (T360) increased in the HSL group, while increasing in the control group up to T30, then decreased gradually until T360. Conclusion: Exogenous lactate in solution has effect as a neuroprotective of brain in the intracerebral hemorrhage (ICH).