Pengaruh Pemberian Partikulat Matter pada Tikus (Rattus Novergicu) Bunting terhadap Cacat Konginetal Resorbsi Embrio

• Main Authors: Widjiati, Eka Pramyrtha Hestianah, Viski Fitri Hendrawan, Epy Muhammad Luqman, Rudi Sukamto
• Format: Article PeerReviewed
• Language: Indonesian; Indonesian
• Published: Fakultas Kedokteran Hewan Universitas Airlangga 2014
• Subjects: SF405.5-407 Laboratory animals; SF811-909 Veterinary medicine of special organs, regions, and systems
• Online Access: http://repository.unair.ac.id/92564/2/Bukti%2012.%20Pengaruh%20Pemberian%20Partikulat%20...._compressed.pdf; http://repository.unair.ac.id/92564/1/Peer%20Review%20Bukti%20C12_compressed.pdf; http://repository.unair.ac.id/92564/
• Institution: Universitas Airlangga

This research is a teratogenic research model intended to observe the effects caused by exposure to particulate matter (PM) which is one of the components of air pollutants which are cytotoxic.This research aims to study the effect of exposure length and dosage of particulate matter on congenital disorder and embryonic resorption . Particulate matter dosage used in this research was 532 mg / m³ and 1064 mg / m³ under the exposure of 4 hours and 8 hours. The observation was made on congenital disorder and the number of embryonic resorption during pregnancy. The results showed that there was a decrease in fetal weight and fetal body length. The fetal weight of KO was (2.18 ± 0.21) , K1 (1.53 ± 0.11) , K2 (1.45 ± 0.98) , K3 (1.26 ± 0.11) and K4 (0 , 39 ± 0.11) . The fetal body length of K0 group was (0.72 ± 0.44) , K1 (0.73 ± 0.75) , K2 (0.23 ± 0.02) , K3 (0.13 ± 0.03) and K4 (0.43 ± 0.00) . on the other hand, there was an increase in the percentage of embryonic resorption in the rats of the treatment groups when compared to the control group K0 (0.0 %) respectively K1 (4.3 %) , K2 (9.5 %) , K3 (22.7 %) and K4 (43.3 %). The conclusion is that the increased dosage and length of exposure to particulate matter reduced the fetal weight and length, but increased the number of embryonic resorptions. Keywords: particulate matter, congenital disorder, resorbtion, placenta