Rare Helicobacter pylori Virulence Genotypes in Bhutan
Both the prevalence of Helicobacter pylori infection and the incidence of gastric cancer are high in Bhutan. The high incidence of atrophic gastritis and gastric cancer suggest the phylogeographic origin of an infection with a more virulent strain of H. pylori. More than 90 of Bhutanese strains poss...
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id-langga.946082020-09-03T06:11:55Z http://repository.unair.ac.id/94608/ Rare Helicobacter pylori Virulence Genotypes in Bhutan Osamu Matsunari Muhammad Miftahussurur Seiji Shiota Rumiko Suzuk Ratha-kornVilaichone Tomohisa Uchida Thawee Ratanachu-ek LotayTshering Varocha Mahachai YoshioYamaoka R Medicine (General) R735-854 Medical education. Medical schools. Research Both the prevalence of Helicobacter pylori infection and the incidence of gastric cancer are high in Bhutan. The high incidence of atrophic gastritis and gastric cancer suggest the phylogeographic origin of an infection with a more virulent strain of H. pylori. More than 90 of Bhutanese strains possessed the highly virulent East Asian-type CagA and all strains had the most virulent type of vacA (s1 type). More than half also had multiple repeats in East Asian-type CagA, which are rare in other countries and are reported characteristictly found in assciation with atrophic gastritis and gastric cancer consistent with Bhutanese strains having multiple H. pylori virulence factors associated with an increase in gastric cancer risk. Phylogeographic analyses showed that most Bhutanese strains belonged to the East Asian population type with some strains (17.5) sharing East Asian and Amerindian components. Only 9.5 belonged to the European type consistant with H. pylori in Bhutan representing an intermediate evolutionary stage between H. pylori from European and East Asian countries. Nature Publishing Group 2016 Article PeerReviewed text en http://repository.unair.ac.id/94608/1/Miftah-Rare%20Helicobacter.pdf Osamu Matsunari and Muhammad Miftahussurur and Seiji Shiota and Rumiko Suzuk and Ratha-kornVilaichone and Tomohisa Uchida and Thawee Ratanachu-ek and LotayTshering and Varocha Mahachai and YoshioYamaoka (2016) Rare Helicobacter pylori Virulence Genotypes in Bhutan. Scientific Reports, 6. ISSN 20452322 https://www.nature.com/articles/srep22584.pdf |
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R Medicine (General) R735-854 Medical education. Medical schools. Research Osamu Matsunari Muhammad Miftahussurur Seiji Shiota Rumiko Suzuk Ratha-kornVilaichone Tomohisa Uchida Thawee Ratanachu-ek LotayTshering Varocha Mahachai YoshioYamaoka Rare Helicobacter pylori Virulence Genotypes in Bhutan |
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Both the prevalence of Helicobacter pylori infection and the incidence of gastric cancer are high in Bhutan. The high incidence of atrophic gastritis and gastric cancer suggest the phylogeographic origin of an infection with a more virulent strain of H. pylori. More than 90 of Bhutanese strains possessed the highly virulent East Asian-type CagA and all strains had the most virulent type of vacA (s1 type). More than half also had multiple repeats in East Asian-type CagA, which are rare in other countries and are reported characteristictly found in assciation with atrophic gastritis and gastric cancer consistent with Bhutanese strains having multiple H. pylori virulence factors associated with an increase in gastric cancer risk. Phylogeographic analyses showed that most Bhutanese strains belonged to the East Asian population type with some strains (17.5) sharing East Asian and Amerindian components. Only 9.5 belonged to the European type consistant with H. pylori in Bhutan representing an intermediate evolutionary stage between H. pylori from European and East Asian countries. |
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Article PeerReviewed |
author |
Osamu Matsunari Muhammad Miftahussurur Seiji Shiota Rumiko Suzuk Ratha-kornVilaichone Tomohisa Uchida Thawee Ratanachu-ek LotayTshering Varocha Mahachai YoshioYamaoka |
author_facet |
Osamu Matsunari Muhammad Miftahussurur Seiji Shiota Rumiko Suzuk Ratha-kornVilaichone Tomohisa Uchida Thawee Ratanachu-ek LotayTshering Varocha Mahachai YoshioYamaoka |
author_sort |
Osamu Matsunari |
title |
Rare Helicobacter pylori Virulence Genotypes in Bhutan |
title_short |
Rare Helicobacter pylori Virulence Genotypes in Bhutan |
title_full |
Rare Helicobacter pylori Virulence Genotypes in Bhutan |
title_fullStr |
Rare Helicobacter pylori Virulence Genotypes in Bhutan |
title_full_unstemmed |
Rare Helicobacter pylori Virulence Genotypes in Bhutan |
title_sort |
rare helicobacter pylori virulence genotypes in bhutan |
publisher |
Nature Publishing Group |
publishDate |
2016 |
url |
http://repository.unair.ac.id/94608/1/Miftah-Rare%20Helicobacter.pdf http://repository.unair.ac.id/94608/ https://www.nature.com/articles/srep22584.pdf |
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