The Effect of Chitosan Type and Concentration on Physical Characteristics and Drug Release Behavior of Andrographolide-Chitosan Microparticles Prepared by Ionic Gelation – Freeze Drying

• Main Authors: Retno Sari, M.L.L. Sugiarto, W. Amirah, Helmy Yusuf
• Format: Book Section PeerReviewed
• Language: English; English; English; English
• Published: Elsevier 2018
• Subjects: R Medicine; RS Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/95329/1/C-21.pdf; http://repository.unair.ac.id/95329/2/C-21-Validasi.pdf; http://repository.unair.ac.id/95329/3/C-21%20Result.pdf; http://repository.unair.ac.id/95329/6/Klarifikasi%20C-21%20bukti%20Korespondensi%20ICoAPS%202018%20Retno%20Sari.pdf; http://repository.unair.ac.id/95329/; https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3461443; https://dx.doi.org/10.2139/ssrn.3461443
• Institution: Universitas Airlangga

Andrographolide is low in solubility and bioavailability, with short half-life (t1/2 = 1.5-2 hours), with chitosan micro-particles expected to improve its dissolution. Therefore, the objective of this research was to investigate the effect of chitosan concentration and the in vitro release of androg...