Comparative Efficacy of Intermittent and Daily Doxazosin Therapy For LUTS Associated With BPH
Objective: To investigate the efficacy of intermittent doxazosin therapy on LUTS associated BPH. Material & Method: This study was performed between January to April 2010 enrolling 20 patients with LUTS associated BPH. Study subjects were randomly allocated to 2 therapeutic groups. The first gr...
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The Indonesian Urological Association
2011
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id-langga.954372020-06-02T02:13:46Z http://repository.unair.ac.id/95437/ Comparative Efficacy of Intermittent and Daily Doxazosin Therapy For LUTS Associated With BPH Heru Nurdianto Sabilal Alif Tarmono Djojodimedjo R Medicine RD Surgery Objective: To investigate the efficacy of intermittent doxazosin therapy on LUTS associated BPH. Material & Method: This study was performed between January to April 2010 enrolling 20 patients with LUTS associated BPH. Study subjects were randomly allocated to 2 therapeutic groups. The first group was assigned daily doxazosin therapy (11 patients), while the second group was assigned intermittent doxazosin therapy (9 patients). Initially all subjects were given doxazosin 2 mg daily for 2 weeks. Subsequently group I received doxazosin 2 mg daily therapy, while group II received doxazosin 2 mg every other day. All medications were taken up to 12 weeks. Outcomes were evaluated prior to therapy, and after 2, 4, 8, and 12 weeks of therapy. Efficacy of doxazosin therapy was measured by International Prostate Symptom Score (IPSS), peak urinary flow rate (Q max), and residual urine volume. Statistical analysis was performed to evaluate difference in efficacy between the treatment groups. Results: Daily doxazosin therapy for 2 weeks resulted in significant improvement of Q max and IPSS. After 4, 8, and 12 weeks significant improvement was maintained in both daily and intermittent groups, as measured by Q max, residual urine volume and IPSS. There were no significant differences in Q max, residual urine volume, and IPSS between the daily and intermittent groups at 4, 8, and 12 groups. Conclusion: There were significant improvements of Q max, residual urine and IPSS at 2 to 12 weeks in daily as well as intermittent doxazosin therapy groups. There were no significant differences in efficacy between daily and intermittent therapy groups The Indonesian Urological Association 2011-01 Article PeerReviewed text en http://repository.unair.ac.id/95437/1/Comparative%20Efficacy%20of%20Intermittent%20and%20Daily%20Doxazosin%20Therapy%20For%20LUTS%20Associated%20With%20BPH.pdf text en http://repository.unair.ac.id/95437/2/Comparative%20Efficacy%20of%20Intermittent%20and%20Daily%20Doxazosin%20Therapy%20For%20LUTS%20Associated%20With%20BPH.pdf text en http://repository.unair.ac.id/95437/3/Comparative%20Efficacy.pdf Heru Nurdianto and Sabilal Alif and Tarmono Djojodimedjo (2011) Comparative Efficacy of Intermittent and Daily Doxazosin Therapy For LUTS Associated With BPH. Indonesian Journal of Urology, 18 (1). pp. 6-12. ISSN 0853-4438 http://juri.urologi.or.id/juri/article/view/66 https://doi.org/10.32421/juri.v18i1.66 |
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R Medicine RD Surgery Heru Nurdianto Sabilal Alif Tarmono Djojodimedjo Comparative Efficacy of Intermittent and Daily Doxazosin Therapy For LUTS Associated With BPH |
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Objective: To investigate the efficacy of intermittent doxazosin therapy on LUTS associated BPH. Material & Method: This study was performed between January to April 2010 enrolling 20 patients with LUTS associated BPH. Study subjects were randomly allocated to 2 therapeutic groups. The first group was assigned daily doxazosin therapy (11 patients), while the second group was assigned intermittent doxazosin therapy (9 patients). Initially all subjects were given doxazosin 2 mg daily for 2 weeks. Subsequently group I received doxazosin 2 mg daily therapy, while group II received doxazosin 2 mg every other day. All medications were taken up to 12 weeks. Outcomes were evaluated prior to therapy, and after 2, 4, 8, and 12 weeks of therapy. Efficacy of doxazosin therapy was measured by International Prostate Symptom Score (IPSS), peak urinary flow rate (Q max), and residual urine volume. Statistical analysis was performed to evaluate difference in efficacy between the treatment groups. Results: Daily doxazosin therapy for 2 weeks resulted in significant improvement of Q max and IPSS. After 4, 8, and 12 weeks significant improvement was maintained in both daily and intermittent groups, as measured by Q max, residual urine volume and IPSS. There were no significant differences in Q max, residual urine volume, and IPSS between the daily and intermittent groups at 4, 8, and 12 groups. Conclusion: There were significant improvements of Q max, residual urine and IPSS at 2 to 12 weeks in daily as well as intermittent doxazosin therapy groups. There were no significant differences in efficacy between daily and intermittent therapy groups |
format |
Article PeerReviewed |
author |
Heru Nurdianto Sabilal Alif Tarmono Djojodimedjo |
author_facet |
Heru Nurdianto Sabilal Alif Tarmono Djojodimedjo |
author_sort |
Heru Nurdianto |
title |
Comparative Efficacy of Intermittent and Daily Doxazosin Therapy For LUTS Associated With BPH |
title_short |
Comparative Efficacy of Intermittent and Daily Doxazosin Therapy For LUTS Associated With BPH |
title_full |
Comparative Efficacy of Intermittent and Daily Doxazosin Therapy For LUTS Associated With BPH |
title_fullStr |
Comparative Efficacy of Intermittent and Daily Doxazosin Therapy For LUTS Associated With BPH |
title_full_unstemmed |
Comparative Efficacy of Intermittent and Daily Doxazosin Therapy For LUTS Associated With BPH |
title_sort |
comparative efficacy of intermittent and daily doxazosin therapy for luts associated with bph |
publisher |
The Indonesian Urological Association |
publishDate |
2011 |
url |
http://repository.unair.ac.id/95437/1/Comparative%20Efficacy%20of%20Intermittent%20and%20Daily%20Doxazosin%20Therapy%20For%20LUTS%20Associated%20With%20BPH.pdf http://repository.unair.ac.id/95437/2/Comparative%20Efficacy%20of%20Intermittent%20and%20Daily%20Doxazosin%20Therapy%20For%20LUTS%20Associated%20With%20BPH.pdf http://repository.unair.ac.id/95437/3/Comparative%20Efficacy.pdf http://repository.unair.ac.id/95437/ http://juri.urologi.or.id/juri/article/view/66 https://doi.org/10.32421/juri.v18i1.66 |
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