Comparison of Fosfomycin Trometamol with Ciprofloxacin for Uncomplicated UTI Due to E, Coli in Women

• Main Authors: Heri Budiono, Sunaryo Hardjowijoto, Tarmono Djojodimedjo, Doddy M. Soebadi, Agung Dwi Wahyu Widodo, Budiono
• Format: Article PeerReviewed
• Language: English; English; English
• Published: The Indonesian Urological Association 2015
• Subjects: R Medicine (General); RD Surgery
• Online Access: http://repository.unair.ac.id/95444/2/Comparison%20of%20Fosfomycin%20Trometamol%20with%20Ciprofloxacin%20for%20Uncomplicated%20UTI%20Due%20to%20E%2C%20Coli%20in%20Women.pdf; http://repository.unair.ac.id/95444/3/Comparison%20of%20Fosfomycin%20Trometamol.pdf; http://repository.unair.ac.id/95444/4/Comparison%20of%20Fosfomycin%20Trometamol.pdf; http://repository.unair.ac.id/95444/; http://juri.urologi.or.id/juri/article/view/96; https://doi.org/10.32421/juri.v22i1.96
• Institution: Universitas Airlangga

Objective: To compare clinical therapeutic effects (frequency, dysuria, and pyuria), microbiology, pharmacokinetics index Cmax/MIC Fosfomycin Trometamol 3 gr single dose with Ciprofloxacin 2 x 500 mg/12 hours for 5 days in the treatment of uncomplicated UTI in women due to Escherichia coli (E.Coli). Materials & Methods: Experimental observational design from February until July 2013. Twenty two women with uncomplicated UTI due to E.Coli performed clinical and microbiological examination. Pharmacokinetics index (Cmax/MIC) is looked for. Patients are divided 2 group, Ciprofloxacin 500 mg/12 hours 5 days and Fosfomycin Trometamol single dose. Repeat clinical and microbiological evaluation is performed in 7 days after therapy. Statistic analysis use Chi Square test, Paired T test, and Independent T test. Results: In the treatment of uncomplicated UTI in women, Fosfomycin Trometamol single dose therapy provides clinical cure (dysuria 81.2%, p = 0.338, frequency 90.9%, p = 0.004, pyuria 90.9%, p = 0.009) much better than Ciprofloxacin 500 mg/12 hours 5 days. Fosfomycin Trometamol single dose therapy also provides bacteriological eradication (100%) better than Ciprofloxacin 500 mg/12 hours 5 days (p = 0.035). Fosfomycin Trometamol single dose had a higher pharmacokinetics index (Cmax/MIC) compared to Ciprofloxacin 500 mg/12 hours (p = 0.035). Conclusion: Fosfomycin Trometamol single dose therapy is superior to Ciprofloxacin 500 mg/12 hours 5 days in the treatment of uncomplicated UTI in women.