Sintesis dan uji in silico turunan asam fenilpropanoat sebagai anti platelet

• Main Authors: Juni Ekowati, Nur Chaulah, Tutuk Budiati
• Format: Article PeerReviewed
• Language: English; English
• Published: Fakultas Farmasi Universitas Airlangga 2014
• Subjects: R Medicine; RS Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/95780/2/Artikel%20C-23.pdf; http://repository.unair.ac.id/95780/1/Validasi%20C-23.pdf; http://repository.unair.ac.id/95780/; http://journal.unair.ac.id/BIKF@sintesis-dan-uji-in-silico--turunan-asam-fenilpropanoat--sebagai-anti-platelet-article-8655-media-96-category-15.html
• Institution: Universitas Airlangga

The objectives of this research were to obtain phenylpropanoic acid derivatives and to approve their activity as antiplatelet. Phenylpropanoic acid and the methoxy substituted of phenylpropanoic acids (ortho and para positions) were synthesized through catalytic hydrogenation of the vynilic double bond of phenylpropenoic acid derivatives. The reaction was carried out at room temperature using Raney-Ni in NaOH condition. The structure of synthesis products were identified by FTIR and 1H-NMR spectroscopy. The yield of phenylpropanoic acid, 3-(4-methoxyphenyl)propanoic acid, 3-(2-methoxyphenyl) propanoic acid were 74%, 61%, 44% respectively. Their activity as antiplatelet was confirmed through in silico study into active site of cyclooxygenase-1 (pdb. 1CQE). The all compounds showed no significantly differences ligand-enzyme interaction energy than acetylsalicylic acid. So, our research concluded that compounds can be used as antiplatelet like acetylsalicylic acid through inhibition of cyclooxygenase-1.