The Role Of JAK2 In Myeloproliferative Diseases Diagnosis
Janus Kinase 2 (JAK2) plays an important role in mediating transduction signal of hematopoiesis, including in the pathogenesis of Myeloproliferative diseases (MPD). Various studies have been carried out to identify the position of aleles in tyrosine encoding mutations. Although the effect of JAK2 mu...
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Faculty of Medicine Universitas Airlangga
2018
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id-langga.962032020-07-27T02:27:51Z http://repository.unair.ac.id/96203/ The Role Of JAK2 In Myeloproliferative Diseases Diagnosis Yudith Annisa Ayu Rezkitha Siprianus Ugroseno Yudho Bintoro Ami Ashariati Prayoga R Medicine (General) RC Internal medicine Janus Kinase 2 (JAK2) plays an important role in mediating transduction signal of hematopoiesis, including in the pathogenesis of Myeloproliferative diseases (MPD). Various studies have been carried out to identify the position of aleles in tyrosine encoding mutations. Although the effect of JAK2 mutations is still not fully understood, the discovery of these mutations might be able to differentiate the types of polycythaemia vera, essential thrombocytemia, and primary myelofibrosis with malignant abnormalities. WHO has revised the MPD diagnosis criteria following this finding. This review will discuss the role of JAK2. Faculty of Medicine Universitas Airlangga 2018 Article PeerReviewed text en http://repository.unair.ac.id/96203/1/The%20Role%20of%20JAK2.pdf text en http://repository.unair.ac.id/96203/2/The%20Role%20Of%20JAK2%20In%20Myeloproliferation.pdf text en http://repository.unair.ac.id/96203/3/The%20Role%20Of%20JAK2%20In%20Myeloproliferative%20Diseases%20Diagnosis.pdf Yudith Annisa Ayu Rezkitha and Siprianus Ugroseno Yudho Bintoro and Ami Ashariati Prayoga (2018) The Role Of JAK2 In Myeloproliferative Diseases Diagnosis. Biomolecular and health science journal, 1 (2). pp. 135-140. ISSN 2620-8636 https://e-journal.unair.ac.id/BHSJ/article/view/9831 http://dx.doi.org/10.20473/bhsj.v1i2.9831 |
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Janus Kinase 2 (JAK2) plays an important role in mediating transduction signal of hematopoiesis, including in the pathogenesis of Myeloproliferative diseases (MPD). Various studies have been carried out to identify the position of aleles in tyrosine encoding mutations. Although the effect of JAK2 mutations is still not fully understood, the discovery of these mutations might be able to differentiate the types of polycythaemia vera, essential thrombocytemia, and primary myelofibrosis with malignant abnormalities. WHO has revised the MPD diagnosis criteria following this finding. This review will discuss the role of JAK2. |
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Article PeerReviewed |
author |
Yudith Annisa Ayu Rezkitha Siprianus Ugroseno Yudho Bintoro Ami Ashariati Prayoga |
author_facet |
Yudith Annisa Ayu Rezkitha Siprianus Ugroseno Yudho Bintoro Ami Ashariati Prayoga |
author_sort |
Yudith Annisa Ayu Rezkitha |
title |
The Role Of JAK2 In Myeloproliferative Diseases Diagnosis |
title_short |
The Role Of JAK2 In Myeloproliferative Diseases Diagnosis |
title_full |
The Role Of JAK2 In Myeloproliferative Diseases Diagnosis |
title_fullStr |
The Role Of JAK2 In Myeloproliferative Diseases Diagnosis |
title_full_unstemmed |
The Role Of JAK2 In Myeloproliferative Diseases Diagnosis |
title_sort |
role of jak2 in myeloproliferative diseases diagnosis |
publisher |
Faculty of Medicine Universitas Airlangga |
publishDate |
2018 |
url |
http://repository.unair.ac.id/96203/1/The%20Role%20of%20JAK2.pdf http://repository.unair.ac.id/96203/2/The%20Role%20Of%20JAK2%20In%20Myeloproliferation.pdf http://repository.unair.ac.id/96203/3/The%20Role%20Of%20JAK2%20In%20Myeloproliferative%20Diseases%20Diagnosis.pdf http://repository.unair.ac.id/96203/ https://e-journal.unair.ac.id/BHSJ/article/view/9831 http://dx.doi.org/10.20473/bhsj.v1i2.9831 |
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