The Effect Of Vitamin C On The Cerebral Cortex Neurons Of Rats Exposed By Prenatal Noise Stress

• Main Authors: Luh Gde Evayanti, Viskasari Pintoko Kalanjati, Abdurachman
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Global Publications 2018
• Subjects: R Medicine (General); RZ Other systems of medicine
• Online Access: http://repository.unair.ac.id/96378/1/The%20Effect%20of%20Vitamin%20C%20on%20The%20Cerebral%20Cortex%20Neurons%20of%20Rats%20Exposed%20by%20Prenatal%20Noise%20Stress.pdf; http://repository.unair.ac.id/96378/2/The%20Effect%20of%20Vitamin%20C%20On%20.pdf; http://repository.unair.ac.id/96378/3/The%20Effect%20of%20Vitamin%20C%20on%20The%20Cerebral%20Cortex%20Neurons%20of%20Rats%20Exposed%20by%20Prenatal%20Noise%20Stress.pdf; http://repository.unair.ac.id/96378/; http://www.envirobiotechjournals.com/article_abstract.php?aid=9054&iid=262&jid=1
• Institution: Universitas Airlangga

The development of cerebral cortex neurons is important due to the complexity of synaptogenesis. Various stressors including prenatal noise exposure may have adverse effect on this process. Vitamin C has been reported to act as an antioxidant in the brain that could function as a reactive oxygen species scavenger and a neuromodulator. Here we investigate the protective effect of vitamin C on the cerebral cortex neurons of the rat offspring exposed by prenatal noise. Twenty-four rat offspring age 0 from 32 pregnant Wistarmothers were divided into 4 groups equally: K1 (distilled water), K2 (vitamin C), P1 (distilled water + noise), P2 (vitamin C + noise). Vitamin C was administered orally 150 mg/kg of body weight, once daily from day 1 of pregnancy until delivery. Prenatal noise exposure was a white noise given 4 hours daily at 95 dB (from day 15 to delivery). The number of neurons from both hemispheres was counted in duplicate from slides stained with hematoxylin-eosin; 4 ì in thickness, parasagittal sliced, 400x of magnification under a light microscope. Data from 4 groups were then analysed using ANOVA and LSD post-test with significance level of p<0.05. The neuron number of P1 is significantly lower compared to the control groups (p=0.006). When compared to P1, the number of the neurons in P2 is significantly higher (p=0.006). From the current study, vitamin C may protect the cerebral cortex from the adverse effect of prenatal noise during pregnancy in rats.