Correlation of Low CD4+ Counts with High Dental Caries Prevalence in Children Living with Perinatal HIV/AIDS Undergoing Antiretroviral Therapy

• Main Authors: Alexander Patera Nugraha, Mario Powa Mensana, Bagus Soebadi, Dominicus Husada, Erwin Astha Triyono, Remita Adya Prasetyo, Diah Savitri Ernawati
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Association of Support to Oral Health Research (APESB) 2019
• Subjects: R Medicine (General); RC Internal medicine
• Online Access: http://repository.unair.ac.id/96473/1/Correlation%20of%20Low%20CD4%2B%20Counts%20with%20High%20Dental%20Caries%20Prevalence%20in%20Children.pdf; http://repository.unair.ac.id/96473/2/Correlation%20of%20Low%20CD4%2B.pdf; http://repository.unair.ac.id/96473/3/Correlation%20of%20Low%20CD4%2B%20Counts%20with%20High%20Dental%20Caries%20Prevalence%20in%20Children%20Living%20with%20Perinatal%20HIV_AIDS%20Undergoing%20Antiretroviral%20Therapy.pdf; http://repository.unair.ac.id/96473/; http://revista.uepb.edu.br/index.php/pboci/article/view/4819; http://dx.doi.org/10.4034/PBOCI.2019.191.119
• Institution: Universitas Airlangga

Objective:To investigate the correlation Cluster of Differentiation 4+(CD4+) counts with a high prevalence of dental caries in Children Living with Perinatal Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (CLWPHA). Material and Methods:An analytical observational research with a cross-sectional design was conducted at Tertiary General Hospital, Surabaya, Indonesia. Randomized total sampling consisted of 29 CLWPHA 1-12 years old at outpatient ward Infectious Disease Intermediate Unit (UPIPI) Tertiary General Hospital Doctor Soetomo Surabaya. Demographic details and recent CD4+counts obtained from medical records. Decayed, missing, filled teeth (dmft) in primary teeth and DMFT in permanent teeth index were used. Pearson's and Spearman's Correlation test (p<0.05) were performed. Results:Dental caries prevalence was 86.2%; meanwhile, the dmft/DMFT index score found were high (8.2 / 6.3). CD4+count and caries showed significant correlation (r=-0.394, p<0.05). Tooth brushing frequency with caries showed a significant correlation (r=-0.419, p<0.05). Antiretroviral (ARV) therapy and caries showed an insignificant negative correlation (p<0.05). Conclusion:The high prevalence of dental caries in CLWPHA correlated with low CD4+counts.