The Association of Lipoprotein-a Levels, Neutrophil Lymphocyte Ratio and Hypertension with the Clinical Severity Scale Measured by NIHSS Scale in Patients with Acute Thrombotic Stroke

• Main Authors: Muhammad Hamdan, Moh. Hasan Machfoed, Paulus Sugianto, Achmad Firdaus Sani, Mohammad Saiful Ardhi, Fadil
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Institute of Medico-legal Publications 2020
• Subjects: R Medicine (General); RA Public aspects of medicine
• Online Access: http://repository.unair.ac.id/97489/1/The%20Association%20of%20Lipoprotein-a%20Levels%2C%20Neutrophil%20Lymphocyte%20Ratio%20and%20Hypertension%20with%20the%20Clinical%20Severity%20Scale%20Measured%20by%20NIHSS%20Scale%20in%20Patients%20with%20Acute%20Thrombotic%20Stroke.pdf; http://repository.unair.ac.id/97489/2/The%20Association%20of%20Lipoprotein.pdf; http://repository.unair.ac.id/97489/3/The%20Association%20of%20Lipoprotein-a%20Levels%2C%20Neutrophil%20Lymphocyte%20Ratio%20and%20Hypertension%20with%20the%20Clinical%20Severity%20Scale%20Measured%20by%20NIHSS%20Scale%20in%20Patients%20with%20Acute%20Thrombotic%20Stroke.pdf; http://repository.unair.ac.id/97489/; https://ijop.net/index.php/mlu/article/view/1187; https://doi.org/10.37506/mlu.v20i2.1187
• Institution: Universitas Airlangga

Background: The correlation between levels of Lipoprotein-a, Neutrophil Lymphocyte Ratio and hypertension with clinical severity scale remains a controversial issue. Objective: To determine the correlation of levels of Lipoprotein-a, Neutrophil Lymphocyte Ratio and hypertension with the severity scale measured by NIHSS scale in patients with acute thrombotic stroke. Method: Lipoprotein-a levels, Neutrophil Lymphocyte ratio, blood pressure in patients with acute thrombotic stroke were measured and clinical severity scale was assessed by NIHSS scale. The levels of lipoprotein-a were grouped into normal and high levels of lipoprotein-a, Lymphocyte Neutrophil Ratios were grouped into low and high and hypertension were grouped into stage 1 and 2. The data was analyzed using logistic regression. Results: There were 40 patients consisting of 29 (72.50%) male patients and 11 (27.50%) female patients. The demographic data included gender, age, LDL level, random blood sugar level, diabetes mellitus status and smoking status which were all homogeneous in both groups of lipoprotein-a, Neutrophil Lymphocyte ratio and hypertension stage. In the logistic regression analysis, the lipoprotein-a and neutrophil lymphocyte ratio were correlated with clinical severity scale (p = 0.018, RO 0.122 (CI 95% 0.022-0.696) vs p = 0.041, RO 0.068 (95% CI 0.005-0.895) while hypertension stage was not correlated with clinical severity scale (p = 0.97, RO 1.02 (95% CI 0.28-3.80). Conclusion: The levels of lipoprotein-a and lymphocyte neutrophil ratio were related to the clinical severity measured by NIHSS scale but not with hypertension.