Synthesis of Some Chalcone Derivatives, in vitro and in Silico Toxicity Evaluation
Chalcone can be synthesized using some methods, but conventional Claisen-Schmidt condensation is still the bestmethod. The objevtives of this study were to synthesize some chalcone derivatives using conventional ClaisenSchmidt condensation by reacting 2-hydroxyacetophenone and some substituted benza...
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| Main Authors: | , , , , , , , , |
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| Format: | Article PeerReviewed |
| Language: | English English English English |
| Published: |
Rasayan Journal
2020
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/98015/1/C09.%20Abstract.pdf http://repository.unair.ac.id/98015/2/C09.%20Fulltext%20-%20SYNTHESIS_RASAYAN.pdf http://repository.unair.ac.id/98015/3/C09.%20Peerreviewer%20-%20Synthesis%20of%20Some%20Chalcone%20Derivatives.pdf http://repository.unair.ac.id/98015/4/C09.%20Similarity%20-%20SYNTHESIS_RASAYAN%20-%20Copy.pdf http://repository.unair.ac.id/98015/ http://dx.doi.org/10.31788/RJC.2020.1315534 |
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| Institution: | Universitas Airlangga |
| Language: | English English English English |
| Summary: | Chalcone can be synthesized using some methods, but conventional Claisen-Schmidt condensation is still the bestmethod. The objevtives of this study were to synthesize some chalcone derivatives using conventional ClaisenSchmidt condensation by reacting 2-hydroxyacetophenone and some substituted benzaldehydes using NaOH 40%, followed by evaluating their cytotoxicity in vitro against HeLa cancer cells line using MTT method and analyzing molecular docking on p53 and MDM2 interaction. Cytotoxicity test exhibited that 2,5-dimethoxy-2´- hydroxychalcone and 4-chloro-2'-hydroxychalcone gave very low IC50, but both did not show potential apoptosis activity, while in docking analysis 4-chloro-2'-hydroxychalcone showing the best results. |
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