Effect of Resveratrol Dimers and Tetramers Isolated from Vitaceous and Dipterocarpaceous Plants on Human SIRT1 Enzyme Activity

• Main Authors: Kiyomi Hikita, Norikazu Seto, Yusuke Takahashi, Ayako Nishigaki, Yuya Suzuki, Tomiyasu Murata, Arthorn Loisruangsin, Nanik Siti Aminah, Yoshiaki Takaya, Masatake Niwa, Norio Kaneda
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Natural Product Communications 2018
• Subjects: Q Science; Q Science (General); QD Chemistry
• Online Access: http://repository.unair.ac.id/98018/1/C11.%20Abstract.pdf; http://repository.unair.ac.id/98018/2/C11.%20Fulltext%20-%20Effect%20of%20Resveratrol_NPC.pdf; http://repository.unair.ac.id/98018/3/C11.%20Peerreviewer%20-%20Effect%20of%20Resveratrol%20Dimers%20and.pdf; http://repository.unair.ac.id/98018/4/C11.%20Similarity%20-%20Effect%20of%20Resveratrol_NPC%20-%20Copy.pdf; http://repository.unair.ac.id/98018/; https://journals.sagepub.com/doi/abs/10.1177/1934578X1801301130; https://doi.org/10.1177/1934578X1801301130
• Institution: Universitas Airlangga

SIRT1 is a mammalian ortholog of the yeast enzyme Sir2, which is an NAD+-dependent deacetylase of histones, p53, FOXO, NF-κB, PGC-1α, and other transcription factors. The Sir2 protein is reported as a longevity protein in yeast. Resveratrol, a polyphenol isolated from various types of plant families...