Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy

• Main Authors: Muhammad Ilham Aldika Akbar, -, Mita Herdiyantini, -, Rozi Aditya Aryananda, -, Nareswari Cininta I, -, Manggala Pasca Wardhana, -, Khanisyah Erza Gumilar, -, Budi Wicaksono, -, Ernawati, -, Agus Sulistyono, -, Aditiawarman, -, Hermanto Tri Joewono, -, Nadir Abdullah, -, Gustaaf Dekker, -, Erry Gumilar Dachlan, -, Muhammad Dikman Angsar, -
• Format: Article PeerReviewed
• Language: English; English; English; English; English; English
• Published: Marcel Dekker Inc. 2018
• Subjects: R Medicine (General); RG Gynecology and obstetrics
• Online Access: https://repository.unair.ac.id/99215/1/I.%2018.%20Serum%20heme%20oxygenase%201%20%28HO-1%29%2C%20soluble%20FMS%20like%20tyrosine%20kinase%20%28sFlt-1%29%20level%2C%20and%20neonatal%20outcome%20in%20early%20onset%2C%20late%20onset%20preeclampsia%2C%20and%20normal%20pregnancy.pdf; https://repository.unair.ac.id/99215/2/Serum%20Heme%20Oxygenase%201%20%28HO-1%29.pdf; https://repository.unair.ac.id/99215/3/Serum%20heme%20oxygenase%201%20%28HO-1%29%2C%20soluble%20FMS%20like%20tyrosine%20kinase%20%28sFlt-1%29%20level%2C%20and%20neonatal%20outcome%20in%20early%20onset%2C%20late%20onset%20preeclampsia%2C%20and%20normal%20pregnancy.pdf; https://repository.unair.ac.id/99215/7/22.%20Agus%20Sulis.pdf; https://repository.unair.ac.id/99215/8/Karil%208.pdf; https://repository.unair.ac.id/99215/10/08.%20artikel.pdf; https://repository.unair.ac.id/99215/; https://www.tandfonline.com/doi/pdf/10.1080/10641955.2018.1494187; https://doi.org/10.1080/10641955.2018.1494187
• Institution: Universitas Airlangga

Objective: To compare the level of serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1), and neonatal outcome in early onset preeclampsia (EO-PE), late onset preeclampsia (LO-PE), and normal pregnancy (NP). Methods: In this prospective observational case control study, HO-1 and sFlt-1 levels were measured in blood samples within 24 h of hospital admission. Preeclampsia cases were divided into two groups based on gestational age at delivery: EO-PE (<34 weeks) and LO-PE (≥34 weeks). A total of 45 patients were involved in this study. Result: Maternal serum level of sFlt-1 was higher in EO-PE than LO-PE and NP groups (mean ± SD; 14.50 ± 17.12 ng/ml vs 5.20 ± 6.69 ng/ml vs 2.72 ± 1.2 ng/ml [p = 0.020]. Maternal serum level of HO-1 was not different between EO-PE, LO-PE, and NP groups (p = 0.681). Birthweights were significantly lower in the EO-PE group compared with the LO-PE and NP groups (1580 ± 536 g vs 2635 ± 578 g vs 3010 ± 371 g [p = 0.000]). The rate of small for gestational age infant (26.7% vs 6.7% vs 0%; p = 0.046) and perinatal death (20% vs 0 vs 0; p = 0.037) was also significantly higher in EO-PE compared to LO-PE and NP. The maternal sFlt-1 level was negatively correlated with birthweight (p = 0.006; CC = −0.445). Conclusion: This study did not find a correlation between maternal HO-1 levels and sFlt-1 levels. Maternal serum sFLt-1 levels in preeclampsia were higher in EO-PE and were associated with a worse perinatal outcome.