Anti Phenolic Glycolipid I (PGLI) of salivary IgA/IgM from Mycobacterium leprosy for early detection of subclinical leprosy

Leprosy is a chronic infectious disease caused by the bacterium Mycobacterium leprae. Indonesia is one of the countries with the highest leprosy, 3rd after India and Brazil. In 2013, Indonesia has 16.856 of new leprosy cases. In diagnosing leprosy, physical clinical examination not always able to d...

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Main Authors: Maria Andisa Mayangsari, -, Muhammad Yoga Wardhana, -, Nastiti Faradilla Ramadhani, -, Alexander Patera Nugraha, -, Rini Devijanti Ridwan, -
Format: Article PeerReviewed
Language:English
English
Indonesian
Published: DR. P. R. YADAV 2020
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Online Access:http://repository.unair.ac.id/99736/1/15_ANTI%20PHENOLIC%20GLYCOLIPID%20I%20%28PGLI%29.pdf
http://repository.unair.ac.id/99736/2/15_Turnitin%2024%20Anti%20phenolic%20glycolipid%20I%20%28PGLI%29%20of%20salivary%20IgA.pdf
http://repository.unair.ac.id/99736/6/validasi%2015.pdf
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spelling id-langga.997362020-10-26T02:12:18Z http://repository.unair.ac.id/99736/ Anti Phenolic Glycolipid I (PGLI) of salivary IgA/IgM from Mycobacterium leprosy for early detection of subclinical leprosy Maria Andisa Mayangsari, - Muhammad Yoga Wardhana, - Nastiti Faradilla Ramadhani, - Alexander Patera Nugraha, - Rini Devijanti Ridwan, - R Medicine RK Dentistry Leprosy is a chronic infectious disease caused by the bacterium Mycobacterium leprae. Indonesia is one of the countries with the highest leprosy, 3rd after India and Brazil. In 2013, Indonesia has 16.856 of new leprosy cases. In diagnosing leprosy, physical clinical examination not always able to detect the early phase of the disease. Therefore, we need a diagnostic tool that can detect infection with Mycobacterium leprae early so that treatment can be performed optimally. Saliva contains a lot of protein and nucleic acid molecules that reflect physiological and pathological status. Through saliva, anti Phenolic glycolipid 1 (anti-PGL1) dan be examined which is a specific antibody against PGL1 M. leprae found in the cell wall. Anti- PGL1is produced as a form of immune response against M. leprae. Individuals with a positive anti-PGL1 shown to have six times greater risk of developing leprosy. Serological examination by ELISA for detection of anti-PGL1 is potential to become a tool for early detection of subclinical leprosy (presence of bacilli), these results are useful to monitor and prevent the possibility of leprosy. Journal and other literature study searched with specific keywords. The result shows salivary anti-PGL1 is representative for M. leprae infection. Examination of anti-PGL1 in saliva can unlock the potential diagnosis of safe, sensitive and non-invasive to leprosy especially in endemic areas. DR. P. R. YADAV 2020 Article PeerReviewed text en http://repository.unair.ac.id/99736/1/15_ANTI%20PHENOLIC%20GLYCOLIPID%20I%20%28PGLI%29.pdf text en http://repository.unair.ac.id/99736/2/15_Turnitin%2024%20Anti%20phenolic%20glycolipid%20I%20%28PGLI%29%20of%20salivary%20IgA.pdf text id http://repository.unair.ac.id/99736/6/validasi%2015.pdf Maria Andisa Mayangsari, - and Muhammad Yoga Wardhana, - and Nastiti Faradilla Ramadhani, - and Alexander Patera Nugraha, - and Rini Devijanti Ridwan, - (2020) Anti Phenolic Glycolipid I (PGLI) of salivary IgA/IgM from Mycobacterium leprosy for early detection of subclinical leprosy. Biochemical and Cellular Archives, 20 (1). pp. 2963-2966. ISSN 09725075
institution Universitas Airlangga
building Universitas Airlangga Library
continent Asia
country Indonesia
Indonesia
content_provider Universitas Airlangga Library
collection UNAIR Repository
language English
English
Indonesian
topic R Medicine
RK Dentistry
spellingShingle R Medicine
RK Dentistry
Maria Andisa Mayangsari, -
Muhammad Yoga Wardhana, -
Nastiti Faradilla Ramadhani, -
Alexander Patera Nugraha, -
Rini Devijanti Ridwan, -
Anti Phenolic Glycolipid I (PGLI) of salivary IgA/IgM from Mycobacterium leprosy for early detection of subclinical leprosy
description Leprosy is a chronic infectious disease caused by the bacterium Mycobacterium leprae. Indonesia is one of the countries with the highest leprosy, 3rd after India and Brazil. In 2013, Indonesia has 16.856 of new leprosy cases. In diagnosing leprosy, physical clinical examination not always able to detect the early phase of the disease. Therefore, we need a diagnostic tool that can detect infection with Mycobacterium leprae early so that treatment can be performed optimally. Saliva contains a lot of protein and nucleic acid molecules that reflect physiological and pathological status. Through saliva, anti Phenolic glycolipid 1 (anti-PGL1) dan be examined which is a specific antibody against PGL1 M. leprae found in the cell wall. Anti- PGL1is produced as a form of immune response against M. leprae. Individuals with a positive anti-PGL1 shown to have six times greater risk of developing leprosy. Serological examination by ELISA for detection of anti-PGL1 is potential to become a tool for early detection of subclinical leprosy (presence of bacilli), these results are useful to monitor and prevent the possibility of leprosy. Journal and other literature study searched with specific keywords. The result shows salivary anti-PGL1 is representative for M. leprae infection. Examination of anti-PGL1 in saliva can unlock the potential diagnosis of safe, sensitive and non-invasive to leprosy especially in endemic areas.
format Article
PeerReviewed
author Maria Andisa Mayangsari, -
Muhammad Yoga Wardhana, -
Nastiti Faradilla Ramadhani, -
Alexander Patera Nugraha, -
Rini Devijanti Ridwan, -
author_facet Maria Andisa Mayangsari, -
Muhammad Yoga Wardhana, -
Nastiti Faradilla Ramadhani, -
Alexander Patera Nugraha, -
Rini Devijanti Ridwan, -
author_sort Maria Andisa Mayangsari, -
title Anti Phenolic Glycolipid I (PGLI) of salivary IgA/IgM from Mycobacterium leprosy for early detection of subclinical leprosy
title_short Anti Phenolic Glycolipid I (PGLI) of salivary IgA/IgM from Mycobacterium leprosy for early detection of subclinical leprosy
title_full Anti Phenolic Glycolipid I (PGLI) of salivary IgA/IgM from Mycobacterium leprosy for early detection of subclinical leprosy
title_fullStr Anti Phenolic Glycolipid I (PGLI) of salivary IgA/IgM from Mycobacterium leprosy for early detection of subclinical leprosy
title_full_unstemmed Anti Phenolic Glycolipid I (PGLI) of salivary IgA/IgM from Mycobacterium leprosy for early detection of subclinical leprosy
title_sort anti phenolic glycolipid i (pgli) of salivary iga/igm from mycobacterium leprosy for early detection of subclinical leprosy
publisher DR. P. R. YADAV
publishDate 2020
url http://repository.unair.ac.id/99736/1/15_ANTI%20PHENOLIC%20GLYCOLIPID%20I%20%28PGLI%29.pdf
http://repository.unair.ac.id/99736/2/15_Turnitin%2024%20Anti%20phenolic%20glycolipid%20I%20%28PGLI%29%20of%20salivary%20IgA.pdf
http://repository.unair.ac.id/99736/6/validasi%2015.pdf
http://repository.unair.ac.id/99736/
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