Early intervention on increasing uterine artery resistance to prevent preeclampsia

• Main Authors: Agus Sulistyono, -, Rachmi, -, Muhammad Ilham Aldika Akbar, -, Budi Wicaksono, -, Ernawati, -, Aditiawarman, -, Hermanto Tri Joewono, -, Erry Gumilar Dachlan, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Elsevier BV 2015
• Subjects: R Medicine (General); RG Gynecology and obstetrics
• Online Access: https://repository.unair.ac.id/99897/1/Early%20Intervention.pdf; https://repository.unair.ac.id/99897/4/1.Dr.Agus%20S.%20%28Early%20Intervention..%29.pdf; https://repository.unair.ac.id/99897/5/Early%20Intervention%20on%20Increasing%20Uterine%20Artery%20Resistance%20to%20Prevent%20Preeclampsia.pdf; https://repository.unair.ac.id/99897/; https://www.sciencedirect.com/science/article/pii/S2210778914003067; https://doi.org/10.1016/j.preghy.2014.10.205

Objectives To evaluate the effectiveness of early intervention with low dose aspirin (LDA) to prevent preeclampsia in the increasing resistance Index (RI) of the uterine artery Doppler velocimetry. Methods The study was done in Ob/Gyn dept. Dr. Soetomo Hospital Surabaya, Indonesia, involving all of pregnant women with 16–22 weeks of gestational age who lived to occupy as a common people in Mulyorejo sub district from January to December 2013. Sonography was performed for gestational age and uterine artery Doppler velocimetry, RI. The result were classified in to 4 classes, Normal (RI 0.38), Class I (RI 0.58), Class II (Diastolic notch (+) with RI 0.58) and Class III (diastolic notch (+) with RI The study was done in Ob/Gyn dept. Dr. Soetomo Hospital Surabaya, Indonesia, involving all of pregnant women with 16–22 weeks of gestational age who lived to occupy as a common people in Mulyorejo sub district from January to December 2013. Sonography was performed for gestational age and uterine artery Doppler velocimetry, RI. The result were classified in to 4 classes, Normal (RI < 0.38), Class I (RI ≥ 0.58), Class II (Diastolic notch (+) with RI < 0.58) and Class III (diastolic notch (+) with RI ≥ 0.58). We gave LDA (81 mg) 1 tablet daily to the Class I, II and III and repeated the sonography after 4 weeks therapy. Results There were 147 pregnant women with 16–22 weeks of pregnancy from 345 pregnant women among 85,292 people who lived in Mulyorejo. The normal results of uterine artery RI were 107 pregnant women, class I, II and III were 15, 9 and 16 cases. From 40 abnormal value, twenty three were re-scanned again after 4 weeks. The results were 5 class I cases becoming normal category but 1 case with pragestational diabetes was increasing to class III. Four class II cases were becoming normal value and 1 still class II. From class III cases decreased to class II, I and normal were 3, 2 and 6 cases, but 1 case still class III. Conclusions LDA was effective to get improved clinical performance by decreasing uterine artery RI in high RI pregnant women at risk of preeclampsia.