KORELASI ANTARA KADAR HbA1c DENGAN OKSIDA NITRIT PADA PEREMPUAN DIABETES MELITUS TIPE 2 DENGAN HIPERTENSI

• Main Authors: , PIPIK RIPAI, , Prof. dr. H. Ahmad H. Asdie SpPD-KEMD
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2012
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/100162/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=56507
• Institution: Universitas Gadjah Mada

Background: One of the complications of type 2 DM are hypertension. The prevalence of hypertension in diabetes 2 times more often than without diabetes. Hypertension in type 2 DM is closely linked to obesity and insulin resistance. Endothelial dysfunction and increased intravascular pressure due to hyperinsulinemia and hyperglycemia, it is possible to directly influence the increase in arterial blood pressure. HbA1c is a glycosylated conjugate hyperglycemia can lead to irreversible changes through the reaction of free amino acids in proteins. Nitric Oxide is an important role for regulation and maintenance of vascular pressure. Several previous studies have agreed that the increase in blood glucose levels can lead to decreased levels of Nitric Oxide in the blood, resulting in impaired vasodilatation resulting in hypertension. Purpose: To analyze the correlation between HbA1c with Nitric Oxide in women with type 2 DM with hypertension. Methods: The study used a cross-sectional design, with age of female subjects with type 2 DM with hypertension 40 to 60 years, they control in clinic of Endocrine and Metabolic RS. Dr. Sardjito Yogyakarta between July 2010 until December 2010 that met inclusion and exclusion criteria. Venous blood samples were then taken for examination and HbA1c levels of Nitric Oxide. The correlation between two variables was analyzed with Pearson correlation test. Considered statistically significant when p <0.05. Results: There are 40 subjects with type 2 DM women with hypertension. Plasma Nitric Oxide levels obtained at 0.61056 ± 0.268172 µmol / L and HbA1c levels of 7.83 ± 2.1671%. Pearson correlation analysis of the results obtained negative correlation between Nitric Oxide levels with levels of HbA1c (r) of -0.124 and no statistically significant with a p value = 0.444. Conclusion: There is no correlation between plasma Nitric Oxide levels with HbA1c levels in subjects with type-2 DM women with hypertension.