Penampilan Diagnostik Content Hemoglobin Reticulocyte (CHr) Untuk Diagnosis Defisiensi Besi Pada Anak Usia 6 bulan-5 Tahun pada waktunya

• Main Authors: , Dea Noviana Pramantik, , dr.Tri Ratnaningsih, M.Kes.,SpPK-K
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2012
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/101094/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=58005
• Institution: Universitas Gadjah Mada

Anemia is a major health problem around the world. World Health Organization estimates that 44.5% of pre school children in Indonesia suffer from anemia and iron deficiency is the major cause. Iron deficiency occurs due to disruption of the balance between the iron supply and the body's iron needs. In children under 5 years iron deficiency will cause disruption in their growth and development. For that reasons iron deficiency in children should be detected as early as possible. Laboratory tests for the detection of iron deficiency divided into hematologic and biochemical examination. Gold standard in the detection of iron deficiency is bone marrow aspiration, but this examination are invasive and difficult to implement. Ferritin is often used to detect iron deficiency but it has various limitations. Reticulocyte hemoglobin content (CHr) was introduced as a new parameter for the identification of iron deficiency. This parameter measures the levels of hemoglobin in the reticulocytes which is newly released from bone marrow and expected to reflect the actual conditions in the bone marrow so it can detect early iron deficiency. It is hoped that CHr can identify iron deficiency with more cheaper, easy, and applicative method. The aims of this study are to determine the diagnostic performance of CHr in the identification of iron deficiency in children aged 6 months to 5 years. This study is a cross sectional study to determine the diagnostic performance of CHr. The subjects of this study were healthy children aged 6 months-5 years taken from Posyandu in Yogyakarta district and has obtained the consent of their parent/guardian. CHr examination using flowcytometry method by Advia 120 Hematology Analyzer. Ferritin examination using electrochemiluminescens methods with Elecsys 1010. The results displayed in the sensitivity, specificity, positive predictive value, and negative predictive value. Determination of CHr cut off using ROC curves.