PERBEDAAN KADAR FIBRINOGEN PLASMA PADA PENDERITA SIROSIS HATI BERDASARKAN KATEGORI FIBROSIS MENGGUNAKAN SKOR FIB-4

• Main Authors: , dr. Heppy Oktavianto, , dr. Neneng Ratnasari, SpPD-KGEH
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2012
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/101116/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=57836
• Institution: Universitas Gadjah Mada

Cirrhosis of the liver disease was a continuation of progressive liver fibrosis in response to chronic liver injury, and the process ended with cirrhosis of the liver and portal hypertension where there was liver failure. In cirrhosis of the liver, there were disturbances of synthesis of clotting factors and anticoagulation, where most of the clotting factors were produced in the liver, including fibrinogen. Noninvasive methods have been developed to assess liver fibrosis and one of noninvasive diagnostic tests to assess liver fibrosis was FIB-4 score there was simple, available, economical, and accurate. This study aimed to determine differences in plasma fibrinogen levels in patients with cirrhosis of the liver by fibrosis category using FIB4 score. The research method used in this study was cross-sectional study. The study was conducted at The Clinic of Gastroentero-Hepatology and Internal Medicine Ward Dr.Sardjito Hospital Yogyakarta from January 2011 until December 2011. Inclusion criteria were patients with cirrhosis of the liver, diagnosed based on clinical criteria, laboratory, and ultrasound liver, adult patients (� 18 years), and signed a research agreement. The exclusion criteria were if having sepsis, other cancers, and immunological disorders. The result showed that the subjects of the study who met the inclusion criteria were 40 people, 25 men (62.5%) and 15 women (37.5%). Average fibrinogen levels in this study were 183.35 (28-629) mg / dL. 4 subjects (10%) in the category of FIB4 <1.45