PENAMPILAN DIAGNOSTIK HEMOG LOBIN A1c UNTUK DIAGNOSIS DIABETES MELITUS TIPE 2 PADA POPULASI DENGAN FAKTOR RISIKO

• Main Authors: , YUNI KUSUMA HARTATIK, , dr. Windarwati, M.Sc, SpPK(K)
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/118565/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=58540
• Institution: Universitas Gadjah Mada

Type 2 diabetes mellitus is a chronic disease that often goes undiagnosed and is not recognized by the patient and cause microvascular and macrovascular complications that can be prevented with early treatment. Therefore we need a diagnosis as early as possible with a valid and reliable diagnostic tool. Hemoglobin A1c � 6.5% is one of the criteria for the diagnosis of type 2 diabetes mellitus according to ADA 2010 and recommended by WHO in 2011. This assay is more convenient, faster and requires no special preparation in comparison with other diagnostic parameters, fasting blood glucose. From previous studies found differences in HbA1c cutoff value in some populations that are likely to be influenced by race and ethnicity. The purpose of this study was to test the appearance of HbA1c diagnosis and determine the cutoff value of HbA1c for the diagnosis of type 2 diabetes mellitus in a population with risk factors. This study used a cross-sectional design and is a diagnostic test with TTGO as gold standard. Subjects were resident in the district Gondokusuman, Banguntapan and Condong Catur who have risk factors for type 2 diabetes mellitus. Examination of HbA1c using HPLC method (Biorad D10). ROC curve analysis performed using computer programme. Sensitivity, specificity, positive predictive value, negative predictive value, accuracy and likelihood ratio was calculated with a 2x2 table. Using Youden�s index, the proper cutoff level of HbA1c for diagnosing type 2 diabetes mellitus. The study was conducted on 235 subjects. Cutoff level of HbA1c was 6.3% on individuals at high risk, sensitivity, specificity, diagnostic accuracy, positive and negative predictive value are 73,1%, 96,7%, 94,04%, 73,1%, 96,7%, respectively. Likelihood ratios positive and negative results are 24,33 and 2,8. HbA1c is expected to diagnose type 2 diabetes mellitus on individuals at high risk.