OPTIMASI FORMULA TABLET FLOATING - GASTRORETENTIVE NIFEDIPIN MENGGUNAKAN METODE EFFERVESCENT DENGAN MATRIKS HPMC K100M DAN ETILSELULOSA

• Main Authors: , INTAN MARTHA CAHYANI, , Prof. Dr. Suwaldi, M, M.Sc., Apt
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/118710/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=58684
• Institution: Universitas Gadjah Mada

Nifedipine is a cardiovascular drug with multiple use frequency within one day for a long period of treatment. The absorption of nifedipine in gastric which reaches 90% (Harjono, 2000) but has low dissolution which can cause the decrease of bioavailability. Gastroretentive drug delivery system (GDDS) using the effervescent is the right choice to ensure patient compliance and therapeutic target. The research aims to know the effect of HPMC K100M, ethylcellulose and an effervescent component on the physical characteristics of the tablet mass (flow rate, angle of repose, true density and compressibility) as well as the physical characteristic of the tablet (hardness, friability, uniformity of content, absorption potency, tablet size, floating lag time and dissolution test) as well as how the composition of each factor to produce the optimum formula. Physical characteristics of the test data were analyzed using the software Minitab 16 factorial design method. Determination of the mechanism of dissolution profiles and curve fitting based on the cumulative weight of nifedipine is released. Interpretation of dissolution profiles seen visually suitability models built from zero-order approximation, first order, Higuchi and Michaelis-Menten against the line of identity on the goodness of fit. The results provide information was obtained that HPMC K100M affected the decrease of floating lag time, DE360 and C360 significantly. Ethylcellulose affered the increase of floating lag time and the decrease in the absorption potency significantly. DE360 and C360 increased because of the significant effervescent component effect. The optimum formula with HPMC K100M 64 mg, ethylcelluloce 52 mg and effervescent component 33 mg gave the result of floating lag time, absorption potency and C360 test which was not significantly different on the minitab 16 prediction result. Curve fitting formed by first-order approach is a model that correspond to the identity line, which means that the release rate is influenced by the amount of nifedipine in tablets dominated diffusion mechanism