EFEKTIFITAS PENAMBAHAN INFUS EFEDRIN 3MG/MENIT 2 MENIT SEBELUM BLOK SUBARAKHNOID DILANJUTKAN 1 MG/MENIT 18 MENIT BERIKUTNYA UNTUK MENGURANGI KEJADIAN HIPOTENSI KARENA BLOK SUBARAKHNOID PADA SEKSIO SESARIA

• Main Authors: , BAMBANG HANTORO SARTI AJI, , Dr.Bambang Suryono Suwondo, Sp.An, KIC, KNA. M.Kes
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/119251/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59246
• Institution: Universitas Gadjah Mada

The objective of the present research was to investigate the prophylactic effectiveness of preloading 20 ml/kg Ringer�s lactate given 30 minutes prior to subarachnoid block, with infusion of 3 mg/minutes ephedrine administered 2 minutes prior to subarachnoid block and 1 mg/minutes of which at 18 minutes afterwards, to reduce the incidence of hypotension among patients undergoing caesarean section. The research design was double blind randomized controlled clinical trial. Altogether 92 female patients (ranging age from, BMI< 35 kg/m2, and ASA I & II physical status) ranging age from 20 to 45 years were enrolled in the study. The scope of this research were full-term pregnant women who underwent elective caesarean section with subarachnoid block anesthesia in Banyumas District Hospital operating room. Subjects were divided into 2 groups, 46 patients of each group. Group A was preloaded by 20ml/kg Ringer�s lactate with infusion of 100 ml 0,9% NaCl+100 mg ephedrine, while group B was preloaded by 20ml/kg Ringer�s lactate and infusion of 100 ml 0,9 NaCl+2 ml 0,9% NaCl. Systolic and diastolic blood pressure, MAP, and SpO2 of all subjects were measured after preloaded by Ringer�s lactate, after ephedrine infusion prior to subarachnoid block, and every 2 minutes until the 20th minute after the subarachnoid block was performed subsequently. Both complication and action rescue were recorded and reported. Using independent samples t � test, we analyzed the quantitative data, while the qualitative data was analyzed by Chi � square at 95% significance level. P < 0,05 and p < 0,001 was considered to be significant and very significant, respectively. The incidence of hypotension was measured by calculating the decline in systolic blood pressure from the baseline. In group A (ephedrine), hypotension was occurred in 7 patients (15,2%), it means incidence of hypotension reduced by 84,8%, while in group B (control) hypotension was occurred in 26 patients (56,5%) or incidence of hypotension reduced by 43,5%. The results suggest that there was significant difference between two groups p < 0,05 (p = 0,001). In conclusion, prophylactic effectiveness of preloading 20 ml/kg Ringer�s lactate given within 30 minutes prior to subarachnoid block, with infusion of 3 mg/minutes ephedrine administered 2 minutes prior to subarachnoid block and 1 mg/minutes of which at 18 minutes afterwards