KADAR LAKTAT SERIAL SEBAGAI FAKTOR PROGNOSIS MORTALITAS PASIEN SEPSIS
Background: Sepsis is a major health problem among children in both developing and industrialized country as a leading cause of death. There are several biomarkers for pediatrics sepsis has been studied. Lactate in recent decades has been studied as a biomarker for critical ill, trauma and sepsis. B...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/119327/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59323 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Background: Sepsis is a major health problem among children in both developing and industrialized country as a leading cause of death. There are
several biomarkers for pediatrics sepsis has been studied. Lactate in recent
decades has been studied as a biomarker for critical ill, trauma and sepsis. Both
elevated level of blood lactate in sepsis indices global tissue hypoxia, increasing
of glycolisis, endotoxin effects and an anaerobic metabolism. Many studies
showed both high level and increasing in serial blood lactate level associated with
increasing risk of mortality in sepsis.
Objective: to determine the association between serial blood lactate level and
mortality in sepsis.
We collected serial blood l
Method: This observational prospective study was performed at Pediatrics
Intensive Care Unit (PICU), Sardjito Hospital, Yogyakarta from July to
November 2012. actate specimens of children with
sepsis fulfilled criteria, at first admission followed by 6 and 24 hours later. The
others examination, laboratory findings, and management of patient was
documented during hospitalized. Outcome measured is mortality at the end of
intensive care. Data were analyzed with bivariate and multivariate analysis.
(50.2%) children from 181 PICU admitted. Only Result: Sepsis was found in 91
75 patient fulfilled the criteria and 5 patients died before 24 hours� lactate
collected. Sepsis proven by positif culture was 57.3% for all cases, in 55
specimens. Septic shock was found in 25 patients (33.3%) and lactic acidosis was
found in 57.3% patients. Thirty nine patients (52.0%) death during study. First
admission and 24 hours of blood lactate level � 4 mmol/L associated with
mortality (RR 2.9 95%CI 1.09-7.66 |
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