PERBEDAAN KADAR ENDOTELIN-1 PADA WANITA DIABETES MELLITUS TIPE 2 DENGAN DAN TANPA HIPERTENSI

• Main Authors: , dr. Enita R Kurniaatmaja, , dr. Hemi Sinorita, SpPD-KEMD
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/119568/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59571
• Institution: Universitas Gadjah Mada

Background. Hypertension and have a strong predisposition on the incidence of atherosclerosis. The incidence of hypertension is two times greater in patients with DM than non DM. Endothelial dysfunction underlies these events. Endothelial markers, endothelin-1 is known affect to affect blood pressure. The aims of this study is to determine the difference levels of endothelin-1 in type 2 diabetes mellitus women with and without hypertension. The subjects were divided into two groups, type 2 DM woman with hypertension groups and without hypertension. ELISA Methods. Cross sectional design was conducted on women with type 2 diabetes mellitus with and without hypertension at metabolic and endocrinology clinic, Dr. Sardjito General Hospital Yogyakarta. sandwich�s method was used to measure plasma levels of endothelin-1. Characteristics of the study are presented in the form of mean and standard deviations. The difference between groups were compared by student�s unpaired t-test an Mann Whitney test. The P value is considered significant if p<0,05 with 95% confidence interval. Conclusion. From this study we expected to know the difference mean levels of endothelin-1 in women with type 2 diabetes with and without hypertension. The levels of endothelin-1 in type 2 DM woman with hypertension higher than those without hypertension