PENGARUH STATUS NUTRISI TERHADAP RESPON TERAPI DAN KESINTASAN PADA PENDERITA KANKER NASOFARING

• Main Authors: , ANDIKA PUTRA SA, , dr. Kartika Widayati, SpPD.,KHOM.
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/120182/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=60202
• Institution: Universitas Gadjah Mada

Background Abstract . Malnutrition in nasopharyngeal cancer (NPC) may influence the response to anti-cancer treatment and survival. Early screening of nutritional status in patients with NPC is very important, so that nutritional intervention can be done. Purpose.Toevaluate effects of malnutrition on treatment response, disease-free survival (DSF) and overall survival (OS). Method.Prospective cohort, where the study was conducted with the resume of a previous pilot study. The study was conducted in dr. Sardjito hospital in Yogyakarta. Before underoing concurrent chemoradiotherapy (CCRT), nutritional status of NPC patients was assessed using the short screening sheet for malnutrition (SSM), then after CCRT, treatment response, DFSand OS assessed to see the relationship with nutritional status. Results. A total of 33 patients entered into the study, from 33 patients were found malnourished group as many as 14 patients (42.42%) and were not malnourished 19 patients (57.58%). After CCRT, the group were not malnourished, which is getting more complete response than getting a non-complete response (16 vs. 3 patients). While the group that malnourished is getting a little more complete response than getting a non-complete response (6 vs. 8 patients), with a p-value (0.013). On the assessment of OS, an average OS rate was lower in the malnourished group compared to the group were not malnourished (22.16 ± 6.07 months vs. 28.59 ± 4.96 months, p = 0,12). On the assessment of DFS rate, an average DFS rate was lower in the malnourished group than in the group not malnourished (19.51 ± 5.10 months vs. 18.67 ± 2.03 months, p = 0,62). Conclusion. Nutritional status of NPC patients corelated with treatment response, patient with well nourished more frequent achieved complete response.