THE DIFFERENCE OF AVERAGE LEVEL OF SERUM N-TERMINAL proB-TYPE NATRIURETIC PEPTIDE (NT-proBNP) IN PATIENTS HYPERTENSION WITHOUT AND WITH LEFT VENTRICULAR HYPERTROPHY AT CARDIOLOGY OUTPATIENT Dr. SARDJITO GENERAL HOSPITAL

• Main Authors: , Gusti Hariyadi Maulana, , dr. Lucia Krisdinarti, SpPD, SpJP(K), FIHA
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/120689/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=60727
• Institution: Universitas Gadjah Mada

Hypertension cause changes in the structure and function of cardial as triggers neurohormonal and vascular changes that concentric cardiac hypertrophy. Myocyte volume expansion or increased pressure will trigger the synthesis of pre-proBrain Natriuretic Peptide (BNP) in the ventricular myocardium. Pre-proBNP will be converted into proBNP and proBNP will be converted into the form of BNP and Nterminal proBNP (NT proBNP). This study aimed to determine differences in NT proBNP in hypertensive patients without LVH and hypertensive patients with LVH. The study design was cross-sectional in cardiology policlinic�s outpatient at Dr. Sardjito General Hospital Yogyakarta from August 2009 until the sample number is fulfilled. To analyze the difference between the two groups of hypertensive patients using the Student t test for normal distribution, while for abnormal distribution were analyzed with the Mann-Whitney U test. To analyze the normality of data conducted Kolmogorov- Smirnov. The differences of two groups of hypertensive patients considered as significant if p < 0.05 with confidence interval of 95%. The results showed 73 study subjects grouped subjects into 2 groups: hypertensive subjects without LVH (31 subjects) and with LVH (42 subjects) based on echocardiography parameters (IVSD, LVPWd, LVIDd, LVM, LVMI) consisting of 24 males and 49 women. The baseline characteristics between the study groups of hypertensive subjects with and without LVH did not differ significantly either in age, BMI, blood pressure, duration of hypertension. Therapeutic characteristics of the use of drugs such as ACEI, ARB, β-blocker, CCB, spironolactone and furosemide. Mean NT proBNP levels in hypertensive group without LVH (46.60 + 45.51) and hypertension with LVH group (201.60 + 192.30 ng / ml). From the results of the Kolmogorov-Smirnov test result that the data distribution is not normal so used Mann-Whitney U test. Obtained a statistically significant difference Conclusion. There were significant differences in the mean levels of serum NT proBNP in hypertensive patients without LVH and hypertensive patients with LVH.