PERANAN GLYCOSILATED HAEMOGLOBIN (HbA1c) TERHADAP DERAJAT NEUROPATI DIABETES MELITUS

• Main Authors: , Ervina Susanti Harahap, , Prof. Dr. dr. Samekto Wibowo, P.Far.K, Sp.FK(K), Sp.S(K).
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/120703/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=60741
• Institution: Universitas Gadjah Mada

Background: high prevalence of diabetic neuropathy, poor of effects, and influence quality of life requires a therapy aimed to prevent progression of neuropathy and improve symptoms by controlling blood sugar levels using glycosylated hemoglobin (HbA1c). Research on the relationship of poor blood sugar control and severity of diabetic neuropathy was still few. Objective: to prove that diabetic neuropathy was most common in high HbA1c, proving that HbA1c was correlated with severity of diabetic neuropathy, and compare the severity of diabetic neuropathy was assessed by HbA1c and blood sugar levels. Method: cross sectional method in patients with diabetes mellitus in Endocrine Polyclinic Dr. Sardjito Hospital Yogyakarta from February to May 2013. Samples were examined NSS, NDS, blood laboratory, electrodiagnostic examination, and performed statistical analysis. Results: 38 samples obtained with a mean HbA1c in neuropathy group was 9,6±2,9% and without neuropathy was 7,4±0,9% (p=0,008). HbA1c in severe neuropathy group was 9,5±2,7%, moderate neuropathy was 8,7±1,8%, mild neuropathy was 8,6±2,5%, and without neuropathy was 7,4±0,9% (p=0,022 , r = 0,381). Mean duration of diabetic in severe, moderate, mild, and without neuropathy was 94,3±71,6, 80,8±85,2, 52,0±13,9 and 31,0±41,9 months (p=0,030, r=0,353). Right and left median nerve conduction velocity and right posterior tibial nerve distal amplitude had a significant relationship with HbA1c (p=0,018, r=0,388) and (p=0,046, r=0,326, p=0,049, r=0,322), whereas for SCS was the right median nerve distal latency (p=0,045, r=0,388). In multivariat analysis showed significant relationship between diabetic duration and severity of neuropathy (p=0,030, r=0,341). Conclusion: diabetic neuropathy was more common in diabetic patients with high HbA1c. HbA1c and long duration of diabetes were associated with severity of diabetic neuropathy. HbA1c had positive correlation with severity of neuropathy clinically and electrodiagnostically. There were difference assesment in severity of diabetic neuropathy between HbA1c and blood sugar levels.