PENGARUH PENGGUNAAN FENILPROPANOLAMIN (PPA) TERHADAP PREEKLAMPSIA/EKLAMPSIA (STUDI KASUS DI RSUP DR. SARDJITO)

• Main Authors: , DITA MARIA VIRGINIA, , Prof. Dr. Djaswadi Dasuki, MPH, Ph.D, Sp. OG(K)
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/120718/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=60756
• Institution: Universitas Gadjah Mada

Background: Preeclampsia causes high morbidity and mortality among maternal in a worldwide. Maternal condition likes influenza disease make them to consume decongestant to relief their flu. Phenylpropanolamine (PPA) is decongestant which widely used in Indonesia and include over the counter (OTC) medicine. PPA is a sympathomitetic agent which it can leads vasoconstriction in circulation. Somehow, it can constricts uterine blood vessels and makes hipoxia in placental areas then it�s possible to get preeclampsia condition. Objectives: To examine the association between the PPA used during pregnancy and preeclampsia in RSUP Dr. Sardjito. Method: A matched case-control study of 68 maternal with an equal number of preeclampsia and non-preeclampsia was conducted among women who delivered infants at Sardjito Hospital, Yogyakarta, Indonesia between November 2013 and February 2013. Data were obtained from medical report and questinnaire and analized using McNemar, and conditional logistic regression to calculate odds ratio (OR) and 95% confidence intervals (CI) of potential risk factors associated with preeclampsia. Result: Maternal who used PPA > 25 mg a day get preeclampsia/eclampsia 5,28 greater than maternal who consume PPA <12,5 mg a day (p=0,05). Bivariat analysis then multivariat result showed no correlation between frequency, duration, and trimester of PPA used with preeclampsia/eclampsia. Conclusion: The used of phenylpropanolamine (PPA) during pregnancy is greater on maternals who get preeclampsia than maternals who do not get preeclampsia at RSUP Dr. Sardjito.