HISTOPATOLOGIS TULANG FEMUR TIKUS (Rattus norvegicus) PASCA IMOBILISASI MENGGUNAKAN PIN DAN XENOGRAFT
A fracture is a bone tissue damage caused by trauma from outside the body or caused by a bone disease that results in loss of continuity. Fracture healing process consists of several phases, namely hematoma, proliferation, callus formation, ossification and bone remodeling. Fracture healing can be m...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/121079/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=61131 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | A fracture is a bone tissue damage caused by trauma from outside the body
or caused by a bone disease that results in loss of continuity. Fracture healing
process consists of several phases, namely hematoma, proliferation, callus
formation, ossification and bone remodeling. Fracture healing can be maximized
with bone graft method, one of them with the use of xenografts is generally
derived from bovine cortical bone. This study aims to reveal the femur bone
histopathology after immobilization with xenograft. Sixteen male rats Rattus
norvegicus 3 months of age were divided into 2 treatment groups, each of 8
rats,namely: 1) Group A (control) mice were created fractures and untreated, 2)
Group B is made up of fracture mice, fixed with intramedular pins and xenograft.
The process of fracture healing in experimental animals based on the results of the
femur bone histopathologic examination were analyzed descriptively.
Histopathologic analysis of the results showed that the activity of osteoclasts
perform bone resorption in a short time, number of osteoblasts increased in a short
time, connective tissue is more dense, cartilage tissue density at four weeks postfracture.
It shows that fractures treated with the xenograft healed better and faster
than without using xenograft. |
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