PENGARUH PEMBERIAN DOSIS EKSTRAK FREEZE JUICING MENGKUDU (Morinda citrifolia) TERHADAP KADAR KOLESTEROL TOTAL DAN HDL-KOLESTEROL PADA TIKUS WISTAR YANG DIINDUKSI DIABETES MELLITUS

• Main Authors: , HARDIANA PROBOSIWI, , Prof. Dr. Ir. Y. Marsono, MS.
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/121548/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=61636
• Institution: Universitas Gadjah Mada

Background : Degenerative illness is becoming more intensive now, since a lot of people have a problem with this illness. One of those illness is Diabetes Mellitus. Inside the diabetes sufferer is almost come with lipid metabolism illness known as dislipidemia. One of medication fruit that could be used to cure this illness is mengkudu. The extract of mengkudu that used to decrease blood cholesterol is antioxidant such as asam ascorbat, beta caroten, flavonoid, and scopoletin. By using freeze juicing process it can eliminate stinky smell from mengkudu. Purpose : To understand the effect of mengkudu extract with freeze juicing method for total cholesterol level and HDL. And also to discover aterogenic index inside of wistar mice with diabetes mellitus. Method : this experiment is quasi experimental using pre and postest by control group design. 30 male wistar mouse with all of them in their second month age. Mice were given AIN-93 in 3 days, and then inducted with Streptozotoxin (45 mg/kg of body weight) and Nicotinamide (110 mg/kg of body weight). After mice have diabetes and then they were divided into five groups, named as negatif control (healthy mice), positif control (DM mice with no treatment) FJ 0.25 (DM mice and given freeze juicing 0.25), FJ 0.5 (DM mice and given freeze juicing 0.5), FJ 1.00 (DM mice and given freeze juicing 1.00). Result : The rate of total cholesterol, HDL, and finale index aterogenic were not make any significant difference in all (p>0.05) treatments. Conclution : Adduction of mengkudu�s freeze juicing extract doesn�t make any significant affection onto total cholesterol, from aterogenic index but has a little amount onto HDL cholesterol inside wistar of mice with diabetes mellitus.