PENGARUH PERBEDAAN KOMPOSISI HIDROGEL-KARBONAT APATIT (CHA) TERHADAP PROFIL PELEPASAN METRONIDAZOLE
anaerobic Dry socket is a common complication and causes a very severe pain after tooth extraction. Patients who experience dry socket have a high number of bacteria, so that the administration of antibacterial is required to reduce the incidence of dry socket. Metronidazole is an antibiotic that is...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
|
| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/122278/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62378 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universitas Gadjah Mada |
| Summary: | anaerobic
Dry socket is a common complication and causes a very severe pain after
tooth extraction. Patients who experience dry socket have a high number of
bacteria, so that the administration of antibacterial is required to reduce
the incidence of dry socket. Metronidazole is an antibiotic that is the safest option
to be used and has been proven to overcome the infections caused by anaerobic
bacteria effectively. Drug delivery system applied into the tooth socket can be
more effective with a carrier material, which is easily resorbed inside the body.
Hydrogel reinforced with carbonate apatite is expected to be an alternative carrier
material for effective drug delivery system in treating dry socket infection. The
aim of this study was to determine the effect of different compositions of the
hydrogel and carbonate apatite on the metronidazole�s release profile.
Hydrogel-carbonate apatite specimens containing the metronidazole were
made by dissolution process of metronidazole into gelatin-carbonate apatite
system. The composition of hydrogel-carbonate apatite used in this study were
varied into three groups: 10:0 |
|---|