ISOLASI DAN IDENTIFIKASI SENYAWA AKTIF ANTIINFLAMASI DARI DAUN Plantago lanceolata
The inhibition of inflammatory signals is considered a promising strategy to combat many disorders as inflammation play a crucial role in the development of those disorders. Plantago lanceolata has been traditionally used to treat inflammation-related disorders and it has potential to be developed a...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Online Access: | https://repository.ugm.ac.id/122757/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62861 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | The inhibition of inflammatory signals is considered a promising strategy to combat many disorders as inflammation play a crucial role in the development of those disorders. Plantago lanceolata has been traditionally used to treat inflammation-related disorders and it has potential to be developed as antiinflammatory agent. The aim of this study was to investigate the antiinflammatory activity of P. lanceolata extract and to identify the active compound responsible for the activity. The dried, powdered leaves of P. lanceolata was macerated three times with dichloromethane (DCM). The dried extract was partitioned with n-hexane to field n-hexane soluble and insoluble fraction. Both fraction were tested tested for their antiinflammatory activities on a thioglikolat-induced peritonitis in mice. Isolation, purification of the active compound was performed using preparative TLC. The our result showed that the n-hexane insoluble fraction was more active than soluble fraction. Isolated compound, done by KLTP was tested antiinflamatory activity. Based on the data spetrofotometri UV, 13C-NMR, 1H-NMR, IR and LC-MS, the active compound was identified as a ursolic acid. This study provides a scientific evidence for the traditional usage of P. lanceolata for the treatment of inflammatory-related diseases. |
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