KORELASI KADAR TUMOR NECROSIS FACTOR -α (TNF-α) DENGAN SKOR CHILD-PUGH PADA PENDERITA SIROSIS HATI

Background.Cirrhosis of the liver is the terminal stage liver disease that is irreversible with high morbidity and mortality. Assessment the severity of liver cirrhosis is based on Child-Pugh score. Tumor Necrosis Factor-α (TNF-α) is proinflammatory cytokine that is associated with the severity of...

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Main Authors: , ZIDNI SETYANINGRUM, , dr. Neneng Ratnasari, SpPD-KGEH
Format: Theses and Dissertations NonPeerReviewed
Published: [Yogyakarta] : Universitas Gadjah Mada 2013
Subjects:
ETD
Online Access:https://repository.ugm.ac.id/122761/
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spelling id-ugm-repo.1227612016-03-04T08:44:54Z https://repository.ugm.ac.id/122761/ KORELASI KADAR TUMOR NECROSIS FACTOR -α (TNF-α) DENGAN SKOR CHILD-PUGH PADA PENDERITA SIROSIS HATI , ZIDNI SETYANINGRUM , dr. Neneng Ratnasari, SpPD-KGEH ETD Background.Cirrhosis of the liver is the terminal stage liver disease that is irreversible with high morbidity and mortality. Assessment the severity of liver cirrhosis is based on Child-Pugh score. Tumor Necrosis Factor-α (TNF-α) is proinflammatory cytokine that is associated with the severity of liver cirrhosis. Level of TNF-α describes severity and extent of liver damage. Aim. The aim of this study is to investigate a correlation between elevated level of TNF-α with elevated Child-Pugh score in patients with liver cirrhosis. Methods. A cross-sectional study was conducted in November 2010 until November 2011. Subyek research were patients with liver cirrhosis who went to a clinic gastroenterohepatologi and in the department of internal medicine wards Sardjito Hospital in Yogyakarta. Collecting data is done by history, physical examination, abdominal ultrasound and blood chemistry measuremen. The level of TNF-α were measured by ELISA. Correlation analysis using Spearman's test. Results. A total subjects were 36 patients with mean of age 54.1 ± 11.4 years old. Median TNF-α level was 28.05 pg / ml (19.4 to 90.4 pg / ml). Median Child-Pugh score was 8 (5-13). There is a very weak positive correlation which statistically not significant between the levels of TNF-α with Child-Pugh score in patients with liver cirrhosis (r = 0.07, p = 0.6). Conclusion.There is no correlation between elevated level of Tumor Necrosis Factor-α (TNF-α) with elevated Child-Pugh score in patients with liver cirrhosis. [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed , ZIDNI SETYANINGRUM and , dr. Neneng Ratnasari, SpPD-KGEH (2013) KORELASI KADAR TUMOR NECROSIS FACTOR -α (TNF-α) DENGAN SKOR CHILD-PUGH PADA PENDERITA SIROSIS HATI. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62866
institution Universitas Gadjah Mada
building UGM Library
country Indonesia
collection Repository Civitas UGM
topic ETD
spellingShingle ETD
, ZIDNI SETYANINGRUM
, dr. Neneng Ratnasari, SpPD-KGEH
KORELASI KADAR TUMOR NECROSIS FACTOR -α (TNF-α) DENGAN SKOR CHILD-PUGH PADA PENDERITA SIROSIS HATI
description Background.Cirrhosis of the liver is the terminal stage liver disease that is irreversible with high morbidity and mortality. Assessment the severity of liver cirrhosis is based on Child-Pugh score. Tumor Necrosis Factor-α (TNF-α) is proinflammatory cytokine that is associated with the severity of liver cirrhosis. Level of TNF-α describes severity and extent of liver damage. Aim. The aim of this study is to investigate a correlation between elevated level of TNF-α with elevated Child-Pugh score in patients with liver cirrhosis. Methods. A cross-sectional study was conducted in November 2010 until November 2011. Subyek research were patients with liver cirrhosis who went to a clinic gastroenterohepatologi and in the department of internal medicine wards Sardjito Hospital in Yogyakarta. Collecting data is done by history, physical examination, abdominal ultrasound and blood chemistry measuremen. The level of TNF-α were measured by ELISA. Correlation analysis using Spearman's test. Results. A total subjects were 36 patients with mean of age 54.1 ± 11.4 years old. Median TNF-α level was 28.05 pg / ml (19.4 to 90.4 pg / ml). Median Child-Pugh score was 8 (5-13). There is a very weak positive correlation which statistically not significant between the levels of TNF-α with Child-Pugh score in patients with liver cirrhosis (r = 0.07, p = 0.6). Conclusion.There is no correlation between elevated level of Tumor Necrosis Factor-α (TNF-α) with elevated Child-Pugh score in patients with liver cirrhosis.
format Theses and Dissertations
NonPeerReviewed
author , ZIDNI SETYANINGRUM
, dr. Neneng Ratnasari, SpPD-KGEH
author_facet , ZIDNI SETYANINGRUM
, dr. Neneng Ratnasari, SpPD-KGEH
author_sort , ZIDNI SETYANINGRUM
title KORELASI KADAR TUMOR NECROSIS FACTOR -α (TNF-α) DENGAN SKOR CHILD-PUGH PADA PENDERITA SIROSIS HATI
title_short KORELASI KADAR TUMOR NECROSIS FACTOR -α (TNF-α) DENGAN SKOR CHILD-PUGH PADA PENDERITA SIROSIS HATI
title_full KORELASI KADAR TUMOR NECROSIS FACTOR -α (TNF-α) DENGAN SKOR CHILD-PUGH PADA PENDERITA SIROSIS HATI
title_fullStr KORELASI KADAR TUMOR NECROSIS FACTOR -α (TNF-α) DENGAN SKOR CHILD-PUGH PADA PENDERITA SIROSIS HATI
title_full_unstemmed KORELASI KADAR TUMOR NECROSIS FACTOR -α (TNF-α) DENGAN SKOR CHILD-PUGH PADA PENDERITA SIROSIS HATI
title_sort korelasi kadar tumor necrosis factor -î± (tnf-î±) dengan skor child-pugh pada penderita sirosis hati
publisher [Yogyakarta] : Universitas Gadjah Mada
publishDate 2013
url https://repository.ugm.ac.id/122761/
http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62866
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