Hubungan antara Ekspresi Ki-67 dengan Kepadatan Limfovaskuler pada Karsinoma Duktal Invasif Payudara
Background: Breast carcinoma metastasis particularly by lymphatic vessel and lymphangiogenesis is the prominent process. Lymphangiogenesis can be detected by lymphovascular density. Uncontrolled cell carcinoma proliferation can induce lymphangiogenesis. Correlation between Ki-67 expression with lymp...
Saved in:
Main Authors: | , |
---|---|
Format: | Theses and Dissertations NonPeerReviewed |
Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
|
Subjects: | |
Online Access: | https://repository.ugm.ac.id/122890/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62999 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universitas Gadjah Mada |
id |
id-ugm-repo.122890 |
---|---|
record_format |
dspace |
spelling |
id-ugm-repo.1228902016-03-04T08:29:55Z https://repository.ugm.ac.id/122890/ Hubungan antara Ekspresi Ki-67 dengan Kepadatan Limfovaskuler pada Karsinoma Duktal Invasif Payudara , DETY NIRBHITA , dr. Irianiwati Widodo, Sp. PA (K). ETD Background: Breast carcinoma metastasis particularly by lymphatic vessel and lymphangiogenesis is the prominent process. Lymphangiogenesis can be detected by lymphovascular density. Uncontrolled cell carcinoma proliferation can induce lymphangiogenesis. Correlation between Ki-67 expression with lymphovascular density need to advance investigated. Aim : To study the correlation between Ki-67 expression and lymphovascular density in ductal invasive breast carcinoma. Method: 39 paraffin embedded tissue of specimen invasive ductal carcinoma of the breast were stained immunohistocemically using Streptavidin-Biotin staining method with monoclonal antibody anti Ki-67 and anti D2- 40. Ki-67 expression was the number of carcinoma cell which nuclear expressed Ki-67. Lymphovascular density was the number of peritumor lymphovascular which endothel cell expressed antibody D2-40. The relationship between each variables were analyzed by chi square method. Result: Statistical analysis showed there was no significant correlation between Ki-67 expression and lymphovascular density in invasive ductal carcinoma of the breast p= 0,905 (p<0,05). Conclusion: In this research, Ki-67 expression is not correlated with lymphovascular density in ductal invasive breast carcinoma. Key: Lymphangiogenesis, Ki-67, Lymphovascular Density, Invasive Ductal Carcinoma of the Breast. [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed , DETY NIRBHITA and , dr. Irianiwati Widodo, Sp. PA (K). (2013) Hubungan antara Ekspresi Ki-67 dengan Kepadatan Limfovaskuler pada Karsinoma Duktal Invasif Payudara. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62999 |
institution |
Universitas Gadjah Mada |
building |
UGM Library |
country |
Indonesia |
collection |
Repository Civitas UGM |
topic |
ETD |
spellingShingle |
ETD , DETY NIRBHITA , dr. Irianiwati Widodo, Sp. PA (K). Hubungan antara Ekspresi Ki-67 dengan Kepadatan Limfovaskuler pada Karsinoma Duktal Invasif Payudara |
description |
Background: Breast carcinoma metastasis particularly by
lymphatic vessel and lymphangiogenesis is the prominent
process. Lymphangiogenesis can be detected by
lymphovascular density. Uncontrolled cell carcinoma
proliferation can induce lymphangiogenesis. Correlation
between Ki-67 expression with lymphovascular density
need to advance investigated.
Aim : To study the correlation between Ki-67 expression
and lymphovascular density in ductal invasive breast
carcinoma.
Method: 39 paraffin embedded tissue of specimen
invasive ductal carcinoma of the breast were stained
immunohistocemically using Streptavidin-Biotin staining
method with monoclonal antibody anti Ki-67 and anti D2-
40. Ki-67 expression was the number of carcinoma cell
which nuclear expressed Ki-67. Lymphovascular density
was the number of peritumor lymphovascular which
endothel cell expressed antibody D2-40. The
relationship between each variables were analyzed by
chi square method.
Result: Statistical analysis showed there was no
significant correlation between Ki-67 expression and
lymphovascular density in invasive ductal carcinoma of
the breast p= 0,905 (p<0,05).
Conclusion: In this research, Ki-67 expression is not
correlated with lymphovascular density in ductal
invasive breast carcinoma.
Key: Lymphangiogenesis, Ki-67, Lymphovascular Density,
Invasive Ductal Carcinoma of the Breast. |
format |
Theses and Dissertations NonPeerReviewed |
author |
, DETY NIRBHITA , dr. Irianiwati Widodo, Sp. PA (K). |
author_facet |
, DETY NIRBHITA , dr. Irianiwati Widodo, Sp. PA (K). |
author_sort |
, DETY NIRBHITA |
title |
Hubungan antara Ekspresi Ki-67 dengan Kepadatan
Limfovaskuler pada Karsinoma Duktal Invasif Payudara |
title_short |
Hubungan antara Ekspresi Ki-67 dengan Kepadatan
Limfovaskuler pada Karsinoma Duktal Invasif Payudara |
title_full |
Hubungan antara Ekspresi Ki-67 dengan Kepadatan
Limfovaskuler pada Karsinoma Duktal Invasif Payudara |
title_fullStr |
Hubungan antara Ekspresi Ki-67 dengan Kepadatan
Limfovaskuler pada Karsinoma Duktal Invasif Payudara |
title_full_unstemmed |
Hubungan antara Ekspresi Ki-67 dengan Kepadatan
Limfovaskuler pada Karsinoma Duktal Invasif Payudara |
title_sort |
hubungan antara ekspresi ki-67 dengan kepadatan
limfovaskuler pada karsinoma duktal invasif payudara |
publisher |
[Yogyakarta] : Universitas Gadjah Mada |
publishDate |
2013 |
url |
https://repository.ugm.ac.id/122890/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62999 |
_version_ |
1681231788218777600 |