OPTIMASI FORMULA TABLET FLOATING NIFEDIPIN MENGGUNAKAN HPMC K15M, PVP K-30 DAN AVICEL PH 102 DENGAN METODE SIMPLEX LATTICE DESIGN
Nifedipine is a drug with a small solubility in water, a consequence, in order to obtain the desired drug release, the solubility of nifedipine should be increased by the addition of PVP K-30. This study was aimed to know the effect of HPMC K15M, PVP K-30 on the release of nifedipin, and Avicel PH 1...
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[Yogyakarta] : Universitas Gadjah Mada
2013
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id-ugm-repo.1233002016-03-04T08:43:17Z https://repository.ugm.ac.id/123300/ OPTIMASI FORMULA TABLET FLOATING NIFEDIPIN MENGGUNAKAN HPMC K15M, PVP K-30 DAN AVICEL PH 102 DENGAN METODE SIMPLEX LATTICE DESIGN , SITI AISIYAH , Prof. Dr. Achmad Fudholi, DEA., Apt. ETD Nifedipine is a drug with a small solubility in water, a consequence, in order to obtain the desired drug release, the solubility of nifedipine should be increased by the addition of PVP K-30. This study was aimed to know the effect of HPMC K15M, PVP K-30 on the release of nifedipin, and Avicel PH 102 on the floating lag time of nifedipin floating tablet, and to find out the proportion of each ingredient to produce the optimum formula of nifedipin floating tablet. The study was conducted using Simplex Lattice Design (SLD) with 3 components i.e. HPMC K15M, PVP K-30 and Avicel PH 102 in order to obtain 14 formulas. The optimization parameter consists of absorption tablet, floating lag time, C360 and DE360. The four parameters were analyzed using Design Expert 7.1.3 software to determine the optimum formula. The optimum formula was obtained by determining the desired target for each parameter. The absorption was selected in maximum target, floating lag time was selected in minimum target, C360 targeted at number 54 and DE360 targeted at number 40. HPMC K15M at the highest concentration affected the smallest release of nifedipin, the highest PVP K-30 concentration affected the most of nifedipin release, whereas high concentration Avicel PH 102 had a small affected reduce in floating lag time of nifedipin floating tablet. The composition of the optimum formula is as follows: 80 mg HPMC K15M, 97 mg PVP K-30 and 45 mg Avicel PH 102. The results of tablet absorption, C360 and DE360 did not differ significantly [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed , SITI AISIYAH and , Prof. Dr. Achmad Fudholi, DEA., Apt. (2013) OPTIMASI FORMULA TABLET FLOATING NIFEDIPIN MENGGUNAKAN HPMC K15M, PVP K-30 DAN AVICEL PH 102 DENGAN METODE SIMPLEX LATTICE DESIGN. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=63411 |
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ETD , SITI AISIYAH , Prof. Dr. Achmad Fudholi, DEA., Apt. OPTIMASI FORMULA TABLET FLOATING NIFEDIPIN MENGGUNAKAN HPMC K15M, PVP K-30 DAN AVICEL PH 102 DENGAN METODE SIMPLEX LATTICE DESIGN |
description |
Nifedipine is a drug with a small solubility in water, a consequence, in order
to obtain the desired drug release, the solubility of nifedipine should be increased
by the addition of PVP K-30. This study was aimed to know the effect of HPMC
K15M, PVP K-30 on the release of nifedipin, and Avicel PH 102 on the floating
lag time of nifedipin floating tablet, and to find out the proportion of each
ingredient to produce the optimum formula of nifedipin floating tablet.
The study was conducted using Simplex Lattice Design (SLD) with 3
components i.e. HPMC K15M, PVP K-30 and Avicel PH 102 in order to obtain
14 formulas. The optimization parameter consists of absorption tablet, floating lag
time, C360 and DE360. The four parameters were analyzed using Design Expert
7.1.3 software to determine the optimum formula. The optimum formula was
obtained by determining the desired target for each parameter. The absorption was
selected in maximum target, floating lag time was selected in minimum target,
C360 targeted at number 54 and DE360 targeted at number 40.
HPMC K15M at the highest concentration affected the smallest release of
nifedipin, the highest PVP K-30 concentration affected the most of nifedipin
release, whereas high concentration Avicel PH 102 had a small affected reduce in
floating lag time of nifedipin floating tablet. The composition of the optimum
formula is as follows: 80 mg HPMC K15M, 97 mg PVP K-30 and 45 mg Avicel
PH 102. The results of tablet absorption, C360 and DE360 did not differ
significantly |
format |
Theses and Dissertations NonPeerReviewed |
author |
, SITI AISIYAH , Prof. Dr. Achmad Fudholi, DEA., Apt. |
author_facet |
, SITI AISIYAH , Prof. Dr. Achmad Fudholi, DEA., Apt. |
author_sort |
, SITI AISIYAH |
title |
OPTIMASI FORMULA TABLET FLOATING NIFEDIPIN MENGGUNAKAN HPMC K15M, PVP K-30 DAN AVICEL PH 102 DENGAN METODE SIMPLEX LATTICE DESIGN |
title_short |
OPTIMASI FORMULA TABLET FLOATING NIFEDIPIN MENGGUNAKAN HPMC K15M, PVP K-30 DAN AVICEL PH 102 DENGAN METODE SIMPLEX LATTICE DESIGN |
title_full |
OPTIMASI FORMULA TABLET FLOATING NIFEDIPIN MENGGUNAKAN HPMC K15M, PVP K-30 DAN AVICEL PH 102 DENGAN METODE SIMPLEX LATTICE DESIGN |
title_fullStr |
OPTIMASI FORMULA TABLET FLOATING NIFEDIPIN MENGGUNAKAN HPMC K15M, PVP K-30 DAN AVICEL PH 102 DENGAN METODE SIMPLEX LATTICE DESIGN |
title_full_unstemmed |
OPTIMASI FORMULA TABLET FLOATING NIFEDIPIN MENGGUNAKAN HPMC K15M, PVP K-30 DAN AVICEL PH 102 DENGAN METODE SIMPLEX LATTICE DESIGN |
title_sort |
optimasi formula tablet floating nifedipin menggunakan hpmc k15m, pvp k-30 dan avicel ph 102 dengan metode simplex lattice design |
publisher |
[Yogyakarta] : Universitas Gadjah Mada |
publishDate |
2013 |
url |
https://repository.ugm.ac.id/123300/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=63411 |
_version_ |
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